2. Gene
  3. Arhgef1 - Rho guanine nucleotide exchange factor (GEF) 1 Gene

Arhgef1 - Rho guanine nucleotide exchange factor (GEF) 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Lsc; Lbcl2

Gene ID: 16801 | Gene type: protein coding

About Arhgef1

Summary

Predicted to enable G protein-coupled receptor binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of cell death. Predicted to be located in cytosol and plasma membrane. Is expressed in brain and heart. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef1 Products(15)

mRNA Protein Name
NM_001130150.2 NP_001123622.1 rho guanine nucleotide exchange factor 1 isoform a
NM_001130151.2 NP_001123623.1 rho guanine nucleotide exchange factor 1 isoform b
NM_001130152.2 NP_001123624.1 rho guanine nucleotide exchange factor 1 isoform c
NM_001130153.2 NP_001123625.1 rho guanine nucleotide exchange factor 1 isoform c
NM_001412640.1 NP_001399569.1 rho guanine nucleotide exchange factor 1 isoform b
NM_001412641.1 NP_001399570.1 rho guanine nucleotide exchange factor 1 isoform b
NM_001412642.1 NP_001399571.1 rho guanine nucleotide exchange factor 1 isoform b
NM_001412643.1 NP_001399572.1 rho guanine nucleotide exchange factor 1 isoform c
NM_001412644.1 NP_001399573.1 rho guanine nucleotide exchange factor 1 isoform d
NM_001412645.1 NP_001399574.1 rho guanine nucleotide exchange factor 1 isoform e
NM_001412646.1 NP_001399575.1 rho guanine nucleotide exchange factor 1 isoform e
NM_001412647.1 NP_001399576.1 rho guanine nucleotide exchange factor 1 isoform f
NM_001412648.1 NP_001399577.1 rho guanine nucleotide exchange factor 1 isoform g
NM_001412649.1 NP_001399578.1 rho guanine nucleotide exchange factor 1 isoform g
NM_008488.3 NP_032514.1 rho guanine nucleotide exchange factor 1 isoform d
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 1

lbc's second cousin

lymphoid blast crisis-like 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00945 ARHGEF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgef1 NCBI NCBI:9138