Arhgef1 - Rho guanine nucleotide exchange factor (GEF) 1 Gene
Also Known as Lsc; Lbcl2
Species: Mus musculus
Gene Type: protein coding
Gene ID: 16801
Summary
Predicted to enable G protein-coupled receptor binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of cell death. Predicted to be located in cytosol and plasma membrane. Is expressed in brain and heart. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Arhgef1 Products (15)
| mRNA | Protein | Name |
|---|---|---|
| NM_001130150.2 | NP_001123622.1 | rho guanine nucleotide exchange factor 1 isoform a |
| NM_001130151.2 | NP_001123623.1 | rho guanine nucleotide exchange factor 1 isoform b |
| NM_001130152.2 | NP_001123624.1 | rho guanine nucleotide exchange factor 1 isoform c |
| NM_001130153.2 | NP_001123625.1 | rho guanine nucleotide exchange factor 1 isoform c |
| NM_001412640.1 | NP_001399569.1 | rho guanine nucleotide exchange factor 1 isoform b |
| NM_001412641.1 | NP_001399570.1 | rho guanine nucleotide exchange factor 1 isoform b |
| NM_001412642.1 | NP_001399571.1 | rho guanine nucleotide exchange factor 1 isoform b |
| NM_001412643.1 | NP_001399572.1 | rho guanine nucleotide exchange factor 1 isoform c |
| NM_001412644.1 | NP_001399573.1 | rho guanine nucleotide exchange factor 1 isoform d |
| NM_001412645.1 | NP_001399574.1 | rho guanine nucleotide exchange factor 1 isoform e |
| NM_001412646.1 | NP_001399575.1 | rho guanine nucleotide exchange factor 1 isoform e |
| NM_001412647.1 | NP_001399576.1 | rho guanine nucleotide exchange factor 1 isoform f |
| NM_001412648.1 | NP_001399577.1 | rho guanine nucleotide exchange factor 1 isoform g |
| NM_001412649.1 | NP_001399578.1 | rho guanine nucleotide exchange factor 1 isoform g |
| NM_008488.3 | NP_032514.1 | rho guanine nucleotide exchange factor 1 isoform d |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15102471 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
rho guanine nucleotide exchange factor 1 |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS00945 | ARHGEF1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Compound Screening Libraries
Virtual Screening
Customize Your Library
Drug Screening Service