ARHGEF1 - Rho guanine nucleotide exchange factor 1 Gene

Also Known as LSC; GEF1; IMD62; LBCL2; SUB1.5; P115-RHOGEF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9138

About ARHGEF1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,883,184-41,930,141 (from NCBI)

This gene has 26 transcripts (splice variants), 201 orthologues, 8 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 68.4), lymph node (RPKM 64.2) and 24 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

ARHGEF1 Products (8)

mRNA Protein Name
NM_001396000.1 NP_001382929.1 rho guanine nucleotide exchange factor 1 isoform 4
NM_001396002.1 NP_001382931.1 rho guanine nucleotide exchange factor 1 isoform 5
NM_001396003.1 NP_001382932.1 rho guanine nucleotide exchange factor 1 isoform 6
NM_001396004.1 NP_001382933.1 rho guanine nucleotide exchange factor 1 isoform 7
NM_001396006.1 NP_001382935.1 rho guanine nucleotide exchange factor 1 isoform 8
NM_004706.4 NP_004697.2 rho guanine nucleotide exchange factor 1 isoform 2
NM_198977.2 NP_945328.1 rho guanine nucleotide exchange factor 1 isoform 3
NM_199002.2 NP_945353.1 rho guanine nucleotide exchange factor 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12681510 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF1 Protein Structure

RGS-like

RGS-like: Regulator of G protein signalling-like domain (42 - 232)

RhoGEF

RhoGEF: RhoGEF domain (420 - 604)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 912 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 1

  • 115 kDa guanine nucleotide exchange factor

ARHGEF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARHGEF1 Q92888 GNA13 Homo sapiens Q14344
Anti Tag CoIP
20300064
Intra
ARHGEF1 Q92888 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
ARHGEF1 Q92888 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Cross
ARHGEF1 Q92888 espH Escherichia coli O157:H7 Q7DB74
IF
20300064
Cross
ARHGEF1 Q92888 espH Escherichia coli O157:H7 Q7DB74
Anti Tag CoIP
20300064
Cross
ARHGEF1 Q92888 espH Escherichia coli O157:H7 Q7DB74
Pull Down
20300064
Cross: Cross-species interaction Intra: Intraspecies interaction

ARHGEF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810957 ARHGEF1 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Immunodeficiency 62

  • IMD62
Skin Lipoma

  • Lipoma Of Skin

  • Cutaneous Lipoma

  • Cutaneous Lipomatous Tumor

  • Lipoma Of Face

  • Cutaneous Lipomatous Neoplasm
Megaesophagus

  • Esophageal Achalasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00945 ARHGEF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARHGEF1 MGD MGI:1353510
Macaca mulatta ARHGEF1 VGNC VGNC:70012
Rattus norvegicus ARHGEF1 RGD RGD:620951
Bos taurus ARHGEF1 VGNC VGNC:52179
Felis catus ARHGEF1 VGNC VGNC:107050
Others ARHGEF1 NCBI