Cry2 - cryptochrome circadian regulator 2 Gene

Rattus norvegicus

Gene ID: 170917 | Gene type: protein coding

About Cry2

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. [provided by RefSeq, Feb 2014]

Cry2 Products(1)

mRNA	Protein	Name
NM_133405.2	NP_596896.2	cryptochrome-2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	11804325	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cryptochrome-2

cryptochrome 2 (photolyase-like)

cryptochrome circadian clock 2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108468	KL001		99.06%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134194	KL201		98.18%	Unkown
HY-134192	TH301		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cry2	NCBI	NCBI:1408
Mus musculus	Cry2	NCBI	NCBI:12953

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