Cry2 - cryptochrome circadian regulator 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170917

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. [provided by RefSeq, Feb 2014]

Cry2 Products (1)

mRNA Protein Name
NM_133405.2 NP_596896.2 cryptochrome-2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
11804325 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cryptochrome-2

  • cryptochrome 2 (photolyase-like)

  • cryptochrome circadian clock 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-108468 KL001 99.06% Phase 1

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134194 KL201 98.18% Unkown
HY-134192 TH301 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cry2 NCBI NCBI:1408