Ppp1r15a - protein phosphatase 1, regulatory subunit 15A Gene

Also Known as Peg-3; Gadd34; Myd116; RGD1624209

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171071

Summary

Enables protein Phosphatase 1 binding activity. Involved in several processes, including cellular response to nutrient levels; cellular response to organonitrogen compound; and regulation of cellular protein metabolic process. Located in cytosol. Biomarker of brain ischemia and transient cerebral ischemia. Orthologous to human PPP1R15A (protein Phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r15a Products (1)

mRNA Protein Name
NM_133546.3 NP_598230.2 protein phosphatase 1 regulatory subunit 15A

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21925170 RGD
enables protein phosphatase 1 binding IDA
IDA: Inferred from direct assay
17760864 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to UV IEP
IEP: Inferred from expression pattern
9811446 RGD
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
21925170 RGD
involved in cellular response to calcium ion starvation IEP
IEP: Inferred from expression pattern
9878749 RGD
involved in cellular response to carbohydrate stimulus IEP
IEP: Inferred from expression pattern
24291486 RGD
involved in cellular response to cordycepin IEP
IEP: Inferred from expression pattern
21597460 RGD
involved in cellular response to desipramine IEP
IEP: Inferred from expression pattern
20549303 RGD
involved in cellular response to gold(3+) IEP
IEP: Inferred from expression pattern
16206274 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
21525936 RGD
involved in cellular response to methamphetamine hydrochloride IEP
IEP: Inferred from expression pattern
22174933 RGD
involved in cellular response to methyl methanesulfonate IEP
IEP: Inferred from expression pattern
9811446 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
9878749 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
23274394 RGD
involved in endoplasmic reticulum unfolded protein response IEP
IEP: Inferred from expression pattern
18266951 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12813455 RGD
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
21925170 RGD
involved in negative regulation of protein processing IMP
IMP: Inferred from mutant phenotype
21925170 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
12813455 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16206274 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15674324 RGD
involved in regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
10611347 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
23644055 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
11389688 RGD
involved in response to environmental enrichment IEP
IEP: Inferred from expression pattern
23644055 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
23644055 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19564919 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 15A

  • growth arrest and DNA damage-inducible protein GADD34

  • myeloid differentiation primary response gene 116

  • myeloid differentiation primary response protein MyD116 homolog

  • progression elevated gene 3 protein

  • protein phosphatase 1, regulatory (inhibitor) s

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-110365 Icerguastat Carbonate Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111022 Icerguastat Inhibitor 99.93% Yes
HY-18956 (E/Z)-Icerguastat Inhibitor 99.44% Unkown
HY-RS10986 PPP1R15A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-18956B (E/Z)-Icerguastat acetate Inhibitor / Unkown
HY-18956A (E/Z)-Icerguastat hydrochloride Inhibitor / Unkown
HY-RS17569 Ppp1r15a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24029 Ppp1r15a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp1r15a NCBI NCBI:23645