LNPEP - Lnpep leucyl and cystinyl aminopeptidase Gene

Also Known as IRAP; GP160; OTase; P-LAP; Vp165

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171105

Summary

Enables Aminopeptidase activity. Involved in several processes, including neuropeptide catabolic process; positive regulation of blood pressure; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including insulin-responsive compartment; neuronal cell body; and perinuclear region of cytoplasm. Colocalizes with vesicle. Used to study type 2 diabetes mellitus. Orthologous to human LNPEP (leucyl and cystinyl Aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

LNPEP Products (1)

mRNA Protein Name
NM_001113403.3 NP_001106874.1 leucyl-cystinyl aminopeptidase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
7559527 RGD
enables aminopeptidase activity IMP
IMP: Inferred from mutant phenotype
16619500 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in neuropeptide catabolic process IMP
IMP: Inferred from mutant phenotype
16771832 RGD
involved in peptide catabolic process IDA
IDA: Inferred from direct assay
7559527 RGD
involved in peptide catabolic process IMP
IMP: Inferred from mutant phenotype
16967782 RGD
involved in positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
11390024 RGD
involved in regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
11282364 RGD
involved in response to hormone IDA
IDA: Inferred from direct assay
12709058 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
16967782 RGD
located in insulin-responsive compartment IDA
IDA: Inferred from direct assay
7559527 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15906313 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9271094 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
27881773 RGD
located in vesicle IDA
IDA: Inferred from direct assay
12709058 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucyl-cystinyl aminopeptidase

  • aminopeptidase Vp165

  • angiotensin IV receptor

  • cystinyl aminopeptidase

  • insulin-regulated membrane aminopeptidase IRAP

  • insulin-responsive aminopeptidase

  • leucyl-cystinyl aminopeptidase-like

  • leucyl/cystinyl aminopeptidase

  • oxytocinase

  • placental leucine

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07730 LNPEP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens LNPEP NCBI NCBI:4012