LNPEP - Lnpep leucyl and cystinyl aminopeptidase Gene

Rattus norvegicus

Also known as IRAP; GP160; OTase; P-LAP; Vp165

Gene ID: 171105 | Gene type: protein coding

About LNPEP

Summary

Enables Aminopeptidase activity. Involved in several processes, including neuropeptide catabolic process; positive regulation of blood pressure; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including insulin-responsive compartment; neuronal cell body; and perinuclear region of cytoplasm. Colocalizes with vesicle. Used to study type 2 diabetes mellitus. Orthologous to human LNPEP (leucyl and cystinyl Aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

LNPEP Products(1)

mRNA	Protein	Name
NM_001113403.3	NP_001106874.1	leucyl-cystinyl aminopeptidase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminopeptidase activity	IDA IDA: Inferred from direct assay	7559527	RGD
enables aminopeptidase activity	IMP IMP: Inferred from mutant phenotype	16619500	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuropeptide catabolic process	IMP IMP: Inferred from mutant phenotype	16771832	RGD
involved in peptide catabolic process	IDA IDA: Inferred from direct assay	7559527	RGD
involved in peptide catabolic process	IMP IMP: Inferred from mutant phenotype	16967782	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	11390024	RGD
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11282364	RGD
involved in response to hormone	IDA IDA: Inferred from direct assay	12709058	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	16967782	RGD
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	7559527	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15906313	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9271094	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	27881773	RGD
located in vesicle	IDA IDA: Inferred from direct assay	12709058	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leucyl-cystinyl aminopeptidase

aminopeptidase Vp165	angiotensin IV receptor
cystinyl aminopeptidase	insulin-regulated membrane aminopeptidase IRAP
insulin-responsive aminopeptidase	leucyl-cystinyl aminopeptidase-like
leucyl/cystinyl aminopeptidase	oxytocinase
placental leucine

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07730	LNPEP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	LNPEP	NCBI	NCBI:4012

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