Mxd3 - Max dimerization protein 3 Gene

Mus musculus

Also known as Mad3; bHLHc13; 4631412E13Rik

Gene ID: 17121 | Gene type: protein coding

About Mxd3

Summary

Contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription, DNA-templated. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; limb mesenchyme; retina; and thymus. Orthologous to human MXD3 (MAX dimerization protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Mxd3 Products(1)

mRNA	Protein	Name
NM_016662.5	NP_057871.2	max dimerization protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to DNA binding	IDA IDA: Inferred from direct assay	8521822	MGI
contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8521822	MGI
contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	8521822	MGI
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	8521822	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8521822	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	8521822	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8521822	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IMP IMP: Inferred from mutant phenotype	8521822	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

max dimerization protein 3

max dimerizer 3

max-associated protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08862	MXD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mxd3	NCBI	NCBI:83463

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