Dnm3 - dynamin 3 Gene

Rattus norvegicus

Also known as dynamin-2

Gene ID: 171574 | Gene type: protein coding

About Dnm3

Summary

Enables G protein-coupled glutamate receptor binding activity; GTPase activity; and nitric-oxide synthase binding activity. A structural constituent of postsynapse. Involved in several processes, including filopodium assembly; postsynaptic neurotransmitter receptor internalization; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including dendritic spine head; postsynaptic density; and synaptic cleft. Part of apical tubulobulbar complex and basal tubulobulbar complex. Is active in glutamatergic synapse and postsynaptic endocytic zone membrane. Orthologous to human DNM3 (Dynamin 3). [provided by Alliance of Genome Resources, Apr 2022]

Dnm3 Products(1)

mRNA	Protein	Name
NM_138538.2	NP_612547.1	dynamin-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	17880892	RGD
enables nitric-oxide synthase binding	IDA IDA: Inferred from direct assay	21490139	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15741233	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	20802490	RGD
enables structural constituent of postsynapse	IDA IDA: Inferred from direct assay	17880892	RGD
enables structural constituent of postsynapse	IMP IMP: Inferred from mutant phenotype	17880892	RGD
enables type 1 metabotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	17880892	RGD
enables type 5 metabotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	17880892	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	17880892	RGD
involved in filopodium assembly	IDA IDA: Inferred from direct assay	12646135	RGD
involved in negative regulation of dendritic spine morphogenesis	IDA IDA: Inferred from direct assay	17880892	RGD
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	17880892	RGD
involved in positive regulation of synaptic vesicle recycling	IMP IMP: Inferred from mutant phenotype	23687302	RGD
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	15741233	RGD
involved in synapse assembly	IDA IDA: Inferred from direct assay	15741233	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of apical tubulobulbar complex	IDA IDA: Inferred from direct assay	17133358	RGD
located in axon	IDA IDA: Inferred from direct assay	17880892	RGD
part of basal tubulobulbar complex	IDA IDA: Inferred from direct assay	17133358	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	17880892	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	17880892	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17880892	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17880892	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15126636	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	12646135	RGD
is active in postsynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	17880892	RGD
is active in postsynaptic endocytic zone membrane	IMP IMP: Inferred from mutant phenotype	17880892	RGD
located in synaptic cleft	IDA IDA: Inferred from direct assay	17880892	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dynamin-3

T-dynamin	dynamin, testicular
testicular dynamin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03906	DNM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnm3	NCBI	NCBI:26052

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