Man2b1 - mannosidase 2, alpha B1 Gene

Also Known as LAMAN

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17159

Summary

Enables alpha-mannosidase activity. Acts upstream of or within learning or memory and mannose metabolic process. Predicted to be located in extracellular space and nucleoplasm. Predicted to be active in lysosome. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study alpha-mannosidosis. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Man2b1 Products (1)

mRNA Protein Name
NM_010764.2 NP_034894.2 lysosomal alpha-mannosidase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-mannosidase activity IDA
IDA: Inferred from direct assay
9305783 MGI
enables alpha-mannosidase activity IMP
IMP: Inferred from mutant phenotype
10400983 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
16014715 MGI
acts upstream of or within mannose metabolic process IDA
IDA: Inferred from direct assay
9305783 MGI
acts upstream of or within mannose metabolic process IMP
IMP: Inferred from mutant phenotype
10400983 MGI
involved in oligosaccharide catabolic process IDA
IDA: Inferred from direct assay
9305783 MGI
Cellular Component GO Annotation Evidence References Source
is active in lysosomal lumen IDA
IDA: Inferred from direct assay
9305783 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysosomal alpha-mannosidase

  • lysosomal acid alpha-mannosidase

  • mannosidase alpha class 2B member 1

  • mannosidase alpha-B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70185 Lysosomal α-mannosidase / Unkown
HY-RS08010 MAN2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Man2b1 NCBI NCBI:4125