Mdfi - MyoD family inhibitor Gene

Mus musculus

Also known as I-mf; I-mfa

Gene ID: 17240 | Gene type: protein coding

About Mdfi

Summary

Enables DNA-binding transcription factor binding activity. Involved in several processes, including dorsal/ventral axis specification; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within embryonic skeletal system morphogenesis and trophoblast giant cell differentiation. Located in nucleus. Is expressed in medulla oblongata basal plate mantle layer; placenta; sensory organ; skeleton; and trophectoderm. Orthologous to human MDFI (MyoD family inhibitor). [provided by Alliance of Genome Resources, Apr 2022]

Mdfi Products(4)

mRNA	Protein	Name
NM_001109973.2	NP_001103443.1	myoD family inhibitor isoform 1
NM_001276390.1	NP_001263319.1	myoD family inhibitor isoform 1
NM_001276391.1	NP_001263320.1	myoD family inhibitor isoform 2 precursor
NM_010783.3	NP_034913.2	myoD family inhibitor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11238923	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12192039	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in dorsal/ventral axis specification	IMP IMP: Inferred from mutant phenotype	11238923	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	9799236	MGI
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	11238923	MGI
involved in negative regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	11238923	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11238923	MGI
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	12192039	MGI
involved in regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	12192039	MGI
acts upstream of or within trophoblast giant cell differentiation	IMP IMP: Inferred from mutant phenotype	9799236	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11238923	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myoD family inhibitor

myogenic repressor I-mf

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08256	MDFI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mdfi	NCBI	NCBI:4188

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