Mdfi - MyoD family inhibitor Gene

Also Known as I-mf; I-mfa

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17240

Summary

Enables DNA-binding transcription factor binding activity. Involved in several processes, including dorsal/ventral axis specification; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within embryonic skeletal system morphogenesis and trophoblast giant cell differentiation. Located in nucleus. Is expressed in medulla oblongata basal plate mantle layer; placenta; sensory organ; skeleton; and trophectoderm. Orthologous to human MDFI (MyoD family inhibitor). [provided by Alliance of Genome Resources, Apr 2022]

Mdfi Products (4)

mRNA Protein Name
NM_001109973.2 NP_001103443.1 myoD family inhibitor isoform 1
NM_001276390.1 NP_001263319.1 myoD family inhibitor isoform 1
NM_001276391.1 NP_001263320.1 myoD family inhibitor isoform 2 precursor
NM_010783.3 NP_034913.2 myoD family inhibitor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11238923 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12192039 MGI
Biological Process GO Annotation Evidence References Source
involved in dorsal/ventral axis specification IMP
IMP: Inferred from mutant phenotype
11238923 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
9799236 MGI
involved in negative regulation of DNA binding IDA
IDA: Inferred from direct assay
11238923 MGI
involved in negative regulation of Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
11238923 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11238923 MGI
involved in regulation of JNK cascade IDA
IDA: Inferred from direct assay
12192039 MGI
involved in regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
12192039 MGI
acts upstream of or within trophoblast giant cell differentiation IMP
IMP: Inferred from mutant phenotype
9799236 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11238923 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myoD family inhibitor

  • myogenic repressor I-mf

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08256 MDFI Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mdfi NCBI NCBI:4188