Mef2b - myocyte enhancer factor 2B Gene

Mus musculus

Gene ID: 17259 | Gene type: protein coding

About Mef2b

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and musculature. Orthologous to human MEF2B (myocyte enhancer factor 2B). [provided by Alliance of Genome Resources, Apr 2022]

Mef2b Products(1)

mRNA	Protein	Name
NM_001045484.2	NP_001038949.1	myocyte-specific enhancer factor 2B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8668199	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	8668199	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12130539	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8668199	MGI
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	17158926	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9443808	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8668199	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12130539	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myocyte-specific enhancer factor 2B

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08310	MEF2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mef2b	NCBI	NCBI:100271849

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