2. Gene
  3. MEF2B - myocyte enhancer factor 2B Gene

MEF2B - myocyte enhancer factor 2B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RSRFR2

Gene ID: 100271849 | Gene type: protein coding

About MEF2B

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,145,567-19,170,263 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues and 4 paralogues. Broad expression in lymph node (RPKM 18.6), appendix (RPKM 7.2) and 17 other tissues.

Summary

The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle Myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (GeneID 729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as GeneID 4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on GeneID 4207. [provided by RefSeq, Jan 2014]

MEF2B Products(2)

mRNA Protein Name
NM_001145785.2 NP_001139257.1 myocyte-specific enhancer factor 2B isoform 1
NM_001367282.1 NP_001354211.1 myocyte-specific enhancer factor 2B isoform 2

MEF2B Protein Structure

SRF-TF

SRF-TF: SRF-type transcription factor (DNA-binding and dimerisation domain) (10 - 59)

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  • 368 a.a.
Protein Preferred Names Protein Names

myocyte-specific enhancer factor 2B

MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B)

Related Diseases

Diseases Alias
Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065
St2 Diffuse Large B-Cell Lymphoma

St2 Dlbcl

Doid:0081068
Brachydactyly, Type E1

Brachydactyly Type E1

Brachydactyly Type E

BDE1

Brachydactyly, Type E

Bde

Type E Brachydactyly

Brachydactyly E1

Brachydactyly Syndrome Type E
Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

Hgbl-Dh/Th

High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements

High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08310 MEF2B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MEF2B RGD RGD:1561733
Mus musculus MEF2B MGD MGI:104526
Felis catus MEF2B VGNC VGNC:102637
Canis familiaris MEF2B VGNC VGNC:108250