CABIN1 - calcineurin binding protein 1 Gene

Also Known as CAIN; PPP3IN; KB-318B8.7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23523

About CABIN1

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:24,011,304-24,178,628 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 212 orthologues. Ubiquitous expression in thyroid (RPKM 6.8), testis (RPKM 6.2) and 25 other tissues.

Summary

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of Calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]

CABIN1 Products (3)

mRNA	Protein	Name
NM_001199281.1	NP_001186210.1	calcineurin-binding protein cabin-1 isoform a
NM_001201429.2	NP_001188358.1	calcineurin-binding protein cabin-1 isoform b
NM_012295.4	NP_036427.1	calcineurin-binding protein cabin-1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12700764	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CABIN1 Protein Structure

TPR_11

MEF2_binding

0
400
800
1200
1600
2000
2220 a.a.

Protein Preferred Names	Protein Names
calcineurin-binding protein cabin-1	calcineurin binding protein cabin 1

CABIN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CABIN1	Q9Y6J0	MEF2B	Homo sapiens	Q02080	EMSA	12700764

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Colloid Adenoma	Macrofollicular Adenoma
Adiaspiromycosis
Fetal Adenoma	Microfollicular Adenoma
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01780	CABIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CABIN1	VGNC	VGNC:38621
Rattus norvegicus	CABIN1	RGD	RGD:620263
Felis catus	CABIN1	VGNC	VGNC:60283
Macaca mulatta	CABIN1	VGNC	VGNC:84563
Mus musculus	CABIN1	MGD	MGI:1298375
Bos taurus	CABIN1	VGNC	VGNC:26663