Bhlha15 - basic helix-loop-helix family, member a15 Gene

Mus musculus

Also known as Mist1; Bhlhb8; MIST-1; 1810009C13Rik

Gene ID: 17341 | Gene type: protein coding

About Bhlha15

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in cellular response to glucose starvation; endoplasmic reticulum unfolded protein response; and negative regulation of myotube differentiation. Acts upstream of or within several processes, including glucose homeostasis; intracellular distribution of mitochondria; and mitochondrial calcium ion transmembrane transport. Located in nucleus. Is expressed in alimentary system; early conceptus; genitourinary system; and limb mesenchyme. Orthologous to human BHLHA15 (basic helix-loop-helix family member a15). [provided by Alliance of Genome Resources, Apr 2022]

Bhlha15 Products(1)

mRNA	Protein	Name
NM_010800.4	NP_034930.1	class A basic helix-loop-helix protein 15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15024058	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15024058	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	15024058	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15024058	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	15024058	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15024058	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11696558	MGI
acts upstream of or within Golgi organization	IMP IMP: Inferred from mutant phenotype	15665001	MGI
acts upstream of or within calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	15665001	MGI
acts upstream of or within cell differentiation	IGI IGI: Inferred from genetic interaction	19013146	MGI
acts upstream of or within cell-cell adhesion mediated by cadherin	IGI IGI: Inferred from genetic interaction	19013146	MGI
acts upstream of or within cell-cell junction organization	IGI IGI: Inferred from genetic interaction	19013146	MGI
acts upstream of or within cell-cell signaling	IMP IMP: Inferred from mutant phenotype	12829745	MGI
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	17612490	MGI
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	17612490	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	15665001	MGI
acts upstream of or within glandular epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	15024058	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	16423820	MGI
acts upstream of or within intracellular distribution of mitochondria	IMP IMP: Inferred from mutant phenotype	15665001	MGI
acts upstream of or within localization of cell	IGI IGI: Inferred from genetic interaction	19013146	MGI
acts upstream of or within mitochondrial calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	15665001	MGI
involved in negative regulation of myotube differentiation	IDA IDA: Inferred from direct assay	17612490	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12829745	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15024058	MGI
acts upstream of or within type B pancreatic cell maturation	IMP IMP: Inferred from mutant phenotype	16423820	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11696558	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

class A basic helix-loop-helix protein 15

basic helix-loop-helix domain containing, class B, 8

muscle, intestine and stomach expression 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01490	BHLHA15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bhlha15	NCBI	NCBI:168620

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