Bhlha15 - basic helix-loop-helix family, member a15 Gene

Also Known as Mist1; Bhlhb8; MIST-1; 1810009C13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17341

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in cellular response to glucose starvation; endoplasmic reticulum unfolded protein response; and negative regulation of myotube differentiation. Acts upstream of or within several processes, including glucose homeostasis; intracellular distribution of mitochondria; and mitochondrial calcium ion transmembrane transport. Located in nucleus. Is expressed in alimentary system; early conceptus; genitourinary system; and limb mesenchyme. Orthologous to human BHLHA15 (basic helix-loop-helix family member a15). [provided by Alliance of Genome Resources, Apr 2022]

Bhlha15 Products (1)

mRNA Protein Name
NM_010800.4 NP_034930.1 class A basic helix-loop-helix protein 15

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15024058 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15024058 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
15024058 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15024058 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
15024058 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
15024058 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11696558 MGI
acts upstream of or within Golgi organization IMP
IMP: Inferred from mutant phenotype
15665001 MGI
acts upstream of or within calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
15665001 MGI
acts upstream of or within cell differentiation IGI
IGI: Inferred from genetic interaction
19013146 MGI
acts upstream of or within cell-cell adhesion mediated by cadherin IGI
IGI: Inferred from genetic interaction
19013146 MGI
acts upstream of or within cell-cell junction organization IGI
IGI: Inferred from genetic interaction
19013146 MGI
acts upstream of or within cell-cell signaling IMP
IMP: Inferred from mutant phenotype
12829745 MGI
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
17612490 MGI
involved in endoplasmic reticulum unfolded protein response IDA
IDA: Inferred from direct assay
17612490 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15665001 MGI
acts upstream of or within glandular epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
15024058 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
16423820 MGI
acts upstream of or within intracellular distribution of mitochondria IMP
IMP: Inferred from mutant phenotype
15665001 MGI
acts upstream of or within localization of cell IGI
IGI: Inferred from genetic interaction
19013146 MGI
acts upstream of or within mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
15665001 MGI
involved in negative regulation of myotube differentiation IDA
IDA: Inferred from direct assay
17612490 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12829745 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15024058 MGI
acts upstream of or within type B pancreatic cell maturation IMP
IMP: Inferred from mutant phenotype
16423820 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11696558 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

class A basic helix-loop-helix protein 15

  • basic helix-loop-helix domain containing, class B, 8

  • muscle, intestine and stomach expression 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01490 BHLHA15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bhlha15 NCBI NCBI:168620