Mknk1 - MAP kinase-interacting serine/threonine kinase 1 Gene

Also Known as Mnk1; 2410048M24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17346

About Mknk1

Chromosome 4: 115,696,395-115,736,447 forward strand.GRCm39:CM000997.3

This gene has 14 transcripts (splice variants), 166 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in thymus adult (RPKM 21.1), lung adult (RPKM 18.5) and 28 other tissues.

Summary

This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Mknk1 Products (5)

mRNA Protein Name
NM_001355174.1 NP_001342103.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform c
NM_021461.5 NP_067436.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform b
NM_001285488.1 NP_001272417.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform b
NM_001285487.1 NP_001272416.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform a
NM_001369238.1 NP_001356167.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9155017 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9155017 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: Inferred from genetic interaction
17903173 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
17903173 MGI
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9155017 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9155017 MGI
involved in response to salt stress IDA
IDA: Inferred from direct assay
9155017 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mknk1 Protein Structure

STKc_Mnk1

STKc_Mnk1: cd14174 (33 - 321)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
Protein Preferred Names Protein Names

MAP kinase-interacting serine/threonine-protein kinase 1

  • MAPK signal-integrating kinase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15514 Merestinib Inhibitor 99.99% Yes
HY-RS08473 MKNK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08474 Mknk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08475 Mknk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mknk1 NCBI NCBI:8569