Mns1 - meiosis-specific nuclear structural protein 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17427

Summary

Predicted to enable identical protein binding activity. Involved in positive regulation of cilium assembly and sperm axoneme assembly. Acts upstream of or within cilium organization and left/right axis specification. Located in cytoskeleton; nuclear envelope; and sperm flagellum. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human MNS1 (meiosis specific nuclear structural 1). [provided by Alliance of Genome Resources, Apr 2022]

Mns1 Products (3)

mRNA Protein Name
NM_001410429.1 NP_001397358.1 meiosis-specific nuclear structural protein 1 isoform 2
NM_001410430.1 NP_001397359.1 meiosis-specific nuclear structural protein 1 isoform 3
NM_008613.4 NP_032639.1 meiosis-specific nuclear structural protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
37198331 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cilium organization IMP
IMP: Inferred from mutant phenotype
22396656 MGI
involved in flagellated sperm motility IDA
IDA: Inferred from direct assay
37295417 MGI
acts upstream of or within left/right axis specification IMP
IMP: Inferred from mutant phenotype
22396656 MGI
involved in positive regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
22396656 MGI
involved in sperm axoneme assembly IMP
IMP: Inferred from mutant phenotype
22396656 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
22396656 MGI
Cellular Component GO Annotation Evidence References Source
is active in axonemal A tubule inner sheath IDA
IDA: Inferred from direct assay
37295417 MGI
located in axoneme IDA
IDA: Inferred from direct assay
22396656 MGI
located in intermediate filament IDA
IDA: Inferred from direct assay
8032679 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
8032679 MGI
is active in sperm flagellum IDA
IDA: Inferred from direct assay
37295417 MGI
located in sperm flagellum IDA
IDA: Inferred from direct assay
22396656 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

meiosis-specific nuclear structural protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08569 MNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mns1 NCBI NCBI:55329