Morc1 - microrchidia 1 Gene

Also Known as Morc

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17450

Summary

Predicted to enable zinc ion binding activity. Involved in negative regulation of gene expression. Acts upstream of or within several processes, including behavioral fear response; gamete generation; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is active in male germ cell nucleus. Is expressed in esophagus; head mesenchyme; musculoskeletal system; and sensory organ. Used to study endogenous depression. Orthologous to human MORC1 (MORC family CW-type zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Morc1 Products (1)

mRNA	Protein	Name
NM_010816.1	NP_034946.1	MORC family CW-type zinc finger protein 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	26275923	MGI
acts upstream of or within epigenetic programing of male pronucleus	IMP IMP: Inferred from mutant phenotype	25503965	MGI
acts upstream of or within epigenetic regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25503965	MGI
acts upstream of or within negative regulation of DNA-templated transcription initiation	IMP IMP: Inferred from mutant phenotype	25503965	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26275923	MGI
acts upstream of retrotransposition	IMP IMP: Inferred from mutant phenotype	25503965	MGI
acts upstream of or within retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	25503965	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	9826705	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	10369865	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in male germ cell nucleus	IDA IDA: Inferred from direct assay	10369865	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	10369865	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10369865	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
MORC family CW-type zinc finger protein 1	protein microrchidia

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08589	MORC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22647	Morc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Morc1	NCBI	NCBI:27136