Gbp4 - guanylate binding protein 4 Gene

Also Known as Mpa2; Mag-2; Mpa-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17472

Summary

Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within several processes, including cellular response to interferon-gamma; negative regulation of macromolecule metabolic process; and negative regulation of protein import into nucleus. Predicted to be active in cytoplasmic vesicle. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]

Gbp4 Products (6)

mRNA Protein Name
NM_001256005.1 NP_001242934.1 macrophage activation 2 isoform 1
NM_001359079.1 NP_001346008.1 macrophage activation 2 isoform 3
NM_001359080.1 NP_001346009.1 macrophage activation 2 isoform 2
NM_001359081.1 NP_001346010.1 macrophage activation 2 isoform 2
NM_001359082.1 NP_001346011.1 macrophage activation 2 isoform 2
NM_008620.4 NP_032646.2 macrophage activation 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22095711 MGI
enables ubiquitin-protein transferase inhibitor activity IDA
IDA: Inferred from direct assay
22095711 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
18025219 MGI
involved in negative regulation of interferon-alpha production IDA
IDA: Inferred from direct assay
22095711 MGI
acts upstream of or within negative regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
22095711 MGI
acts upstream of or within negative regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
22095711 MGI
acts upstream of or within negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
22095711 MGI
acts upstream of or within negative regulation of protein ubiquitination IGI
IGI: Inferred from genetic interaction
22095711 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22095711 MGI
acts upstream of or within regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
22095711 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage activation 2

  • guanylate nucleotide binding protein 4

  • guanylate-binding protein 4 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05310 GBP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18935 Gbp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22180 Gbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25425 Gbp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gbp4 NCBI NCBI:115361