Mpdz - multiple PDZ domain crumbs cell polarity complex component Gene

Also Known as MUPP1; B930003D11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17475

Summary

Predicted to enable protein C-terminus binding activity. Involved in dendrite development and intracellular protein transport. Acts upstream of or within cell adhesion. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and bicellular tight junction. Part of subapical complex. Is active in synapse. Is expressed in several structures, including central nervous system; early conceptus; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human MPDZ (multiple PDZ domain crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Apr 2022]

Mpdz Products (3)

mRNA Protein Name
NM_001305284.1 NP_001292213.1 multiple PDZ domain protein isoform 1
NM_001305286.1 NP_001292215.1 multiple PDZ domain protein isoform 3
NM_010820.3 NP_034950.2 multiple PDZ domain protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11018522 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
11689568 MGI
involved in dendrite development IMP
IMP: Inferred from mutant phenotype
25977097 MGI
involved in intracellular protein transport IMP
IMP: Inferred from mutant phenotype
25977097 MGI
Cellular Component GO Annotation Evidence References Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
20237282 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
17397395 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
11689568 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17397395 MGI
part of subapical complex IDA
IDA: Inferred from direct assay
16885194 MGI
is active in synapse IDA
IDA: Inferred from direct assay
25977097 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

multiple PDZ domain protein

  • multi-PDZ domain protein 1

Mpdz Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Mpdz Q8VBX6 KIT Homo sapiens P10721
Y2H
11018522
Cross
Mpdz Q8VBX6 KIT Homo sapiens P10721
Pull Down
11018522
Intra
Mpdz Q8VBX6 Cldn1 Mus musculus O88551
Y2H Pooling
11689568
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07732 LNX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08609 MPDZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpdz NCBI NCBI:8777