Mpdz - multiple PDZ domain crumbs cell polarity complex component Gene

Mus musculus

Also known as MUPP1; B930003D11Rik

Gene ID: 17475 | Gene type: protein coding

About Mpdz

Summary

Predicted to enable protein C-terminus binding activity. Involved in dendrite development and intracellular protein transport. Acts upstream of or within cell adhesion. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and bicellular tight junction. Part of subapical complex. Is active in synapse. Is expressed in several structures, including central nervous system; early conceptus; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human MPDZ (multiple PDZ domain crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Apr 2022]

Mpdz Products(3)

mRNA	Protein	Name
NM_001305284.1	NP_001292213.1	multiple PDZ domain protein isoform 1
NM_001305286.1	NP_001292215.1	multiple PDZ domain protein isoform 3
NM_010820.3	NP_034950.2	multiple PDZ domain protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11018522	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell adhesion	IDA IDA: Inferred from direct assay	11689568	MGI
involved in dendrite development	IMP IMP: Inferred from mutant phenotype	25977097	MGI
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	25977097	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	20237282	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17397395	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	11689568	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17397395	MGI
part of subapical complex	IDA IDA: Inferred from direct assay	16885194	MGI
is active in synapse	IDA IDA: Inferred from direct assay	25977097	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

multiple PDZ domain protein

multi-PDZ domain protein 1

Mpdz Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Mpdz	Q8VBX6	KIT	Homo sapiens	P10721	Y2H	11018522
Cross	Mpdz	Q8VBX6	KIT	Homo sapiens	P10721	Pull Down	11018522
Intra	Mpdz	Q8VBX6	Cldn1	Mus musculus	O88551	Y2H Pooling	11689568

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07732	LNX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08609	MPDZ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mpdz	NCBI	NCBI:8777

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