Myo15a - myosin XVA Gene

Mus musculus

Also known as sh2; sh-2; Myo15

Gene ID: 17910 | Gene type: protein coding

About Myo15a

Summary

Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within inner ear morphogenesis; locomotory behavior; and sensory perception of sound. Located in stereocilium. Is expressed in several structures, including heart; inner ear; liver; metanephros; and skeletal muscle. Used to study autosomal recessive nonsyndromic deafness 3. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (Myosin XVA). [provided by Alliance of Genome Resources, Apr 2022]

Myo15a Products(3)

mRNA	Protein	Name
NM_001103171.1	NP_001096641.1	unconventional myosin-XV isoform 3
NM_010862.2	NP_034992.2	unconventional myosin-XV isoform 1
NM_182698.2	NP_874357.2	unconventional myosin-XV isoform 2a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15590698	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	11718241	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	16962269	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	11718241	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in stereocilium	IDA IDA: Inferred from direct assay	20016102	MGI
located in stereocilium bundle	IDA IDA: Inferred from direct assay	20016102	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

unconventional myosin-XV

shaker 2

unconventional myosin-15

Myo15a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Myo15a	Q9QZZ4	Whrn	Mus musculus	Q80VW5	Pull Down	15590698
Intra	Myo15a	Q9QZZ4	Whrn	Mus musculus	Q80VW5	IF	15590698

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08931	MYO15A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo15a	NCBI	NCBI:51168

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