Myo15a - myosin XVA Gene

Also Known as sh2; sh-2; Myo15

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17910

Summary

Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within inner ear morphogenesis; locomotory behavior; and sensory perception of sound. Located in stereocilium. Is expressed in several structures, including heart; inner ear; liver; metanephros; and skeletal muscle. Used to study autosomal recessive nonsyndromic deafness 3. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (Myosin XVA). [provided by Alliance of Genome Resources, Apr 2022]

Myo15a Products (3)

mRNA Protein Name
NM_001103171.1 NP_001096641.1 unconventional myosin-XV isoform 3
NM_010862.2 NP_034992.2 unconventional myosin-XV isoform 1
NM_182698.2 NP_874357.2 unconventional myosin-XV isoform 2a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15590698 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
11718241 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
16962269 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
11718241 MGI
Cellular Component GO Annotation Evidence References Source
located in stereocilium IDA
IDA: Inferred from direct assay
20016102 MGI
located in stereocilium bundle IDA
IDA: Inferred from direct assay
20016102 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unconventional myosin-XV

  • shaker 2

  • unconventional myosin-15

Myo15a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Myo15a Q9QZZ4 Whrn Mus musculus Q80VW5
Pull Down
15590698
Intra
Myo15a Q9QZZ4 Whrn Mus musculus Q80VW5
IF
15590698
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08931 MYO15A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo15a NCBI NCBI:51168