Ppp1r12a - protein phosphatase 1, regulatory subunit 12A Gene

Also Known as Mypt1; D10Ertd625e; 1200015F06Rik; 5730577I22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17931

Summary

Predicted to enable several functions, including 14-3-3 protein binding activity; Phosphatase regulator activity; and protein kinase binding activity. Acts upstream of or within cellular response to xenobiotic stimulus; protein dephosphorylation; and regulation of nucleocytoplasmic transport. Located in A band and Z disc. Is expressed in corpus striatum; genital tubercle epithelium; head mesenchyme; urethra epithelium; and urothelium. Orthologous to human PPP1R12A (protein Phosphatase 1 regulatory subunit 12A). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r12a Products (3)

mRNA Protein Name
NM_001368736.1 NP_001355665.1 protein phosphatase 1 regulatory subunit 12A isoform 1
NM_001368737.1 NP_001355666.1 protein phosphatase 1 regulatory subunit 12A isoform 3
NM_027892.3 NP_082168.1 protein phosphatase 1 regulatory subunit 12A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18448676 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
18524939 MGI
acts upstream of or within protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
17369396 MGI
acts upstream of or within regulation of nucleocytoplasmic transport IMP
IMP: Inferred from mutant phenotype
17369396 MGI
Cellular Component GO Annotation Evidence References Source
located in A band IDA
IDA: Inferred from direct assay
11067852 MGI
located in Z disc IDA
IDA: Inferred from direct assay
11067852 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 12A

  • myosin phosphatase target subunit 1

  • myosin phosphatase-targeting subunit 1

  • protein phosphatase 1, regulatory (inhibitor) subunit 12A

Ppp1r12a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ppp1r12a Q9DBR7 Prkg1 Mus musculus P0C605-1
Pull Down
18448676
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10978 PPP1R12A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp1r12a NCBI NCBI:4659