Neo1 - neogenin Gene

Also Known as Igdcc2; 2610028H22Rik; D930014N22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18007

Summary

Enables BMP Receptor binding activity; Cadherin binding activity; and signaling receptor activity. Acts upstream of or within several processes, including myoblast fusion; negative regulation of axon regeneration; and positive regulation of BMP signaling pathway. Located in cell surface; intracellular vesicle; and membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human NEO1 (neogenin 1). [provided by Alliance of Genome Resources, Apr 2022]

Neo1 Products (11)

mRNA Protein Name
NM_001042752.2 NP_001036217.1 neogenin isoform 2 precursor
NM_001408269.1 NP_001395198.1 neogenin isoform 3 precursor
NM_001408270.1 NP_001395199.1 neogenin isoform 4 precursor
NM_001408271.1 NP_001395200.1 neogenin isoform 5 precursor
NM_001408272.1 NP_001395201.1 neogenin isoform 6 precursor
NM_001408273.1 NP_001395202.1 neogenin isoform 7 precursor
NM_001408274.1 NP_001395203.1 neogenin isoform 8 precursor
NM_001408275.1 NP_001395204.1 neogenin isoform 9 precursor
NM_001408276.1 NP_001395205.1 neogenin isoform 10 precursor
NM_001408277.1 NP_001395206.1 neogenin isoform 11 precursor
NM_008684.3 NP_032710.2 neogenin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BMP receptor binding IPI
IPI: Inferred from physical interaction
18326817 MGI
enables cadherin binding IDA
IDA: Inferred from direct assay
15520228 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15520228 MGI
enables signaling receptor activity IPI
IPI: Inferred from physical interaction
15520228 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
20065295 MGI
acts upstream of or within myoblast fusion IMP
IMP: Inferred from mutant phenotype
15520228 MGI
acts upstream of or within negative regulation of axon regeneration IMP
IMP: Inferred from mutant phenotype
26651291 MGI
acts upstream of or within negative regulation of protein secretion IDA
IDA: Inferred from direct assay
20065295 MGI
acts upstream of or within positive regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
20065295 MGI
acts upstream of protein secretion IDA
IDA: Inferred from direct assay
20065295 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15520228 MGI
acts upstream of or within regulation of axon regeneration IGI
IGI: Inferred from genetic interaction
26651291 MGI
involved in trans-synaptic signaling, modulating synaptic transmission IDA
IDA: Inferred from direct assay
35544694 MGI
involved in trans-synaptic signaling, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
35544694 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
26651291 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
35544694 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
35544694 MGI
located in growth cone IDA
IDA: Inferred from direct assay
26651291 MGI
located in intracellular vesicle IDA
IDA: Inferred from direct assay
26651291 MGI
located in membrane IDA
IDA: Inferred from direct assay
26651291 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
35544694 MGI
is active in postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
35544694 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neogenin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09209 NEO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22250 Neo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28772 Neo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Neo1 NCBI NCBI:4756