NEO1 - neogenin 1 Gene

Also Known as NGN; IGDCC2; NTN1R2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4756

About NEO1

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,051,692-73,305,206 (from NCBI)

This gene has 11 transcripts (splice variants), 244 orthologues and 36 paralogues. Broad expression in colon (RPKM 23.2), skin (RPKM 16.0) and 23 other tissues.

Summary

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

NEO1 Products (3)

mRNA Protein Name
NM_001172623.1 NP_001166094.1 neogenin isoform 2 precursor
NM_001172624.1 NP_001166095.1 neogenin isoform 3 precursor
NM_002499.4 NP_002490.2 neogenin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables co-receptor binding IPI
IPI: Inferred from physical interaction
18335997 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18335997 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within multicellular organismal-level iron ion homeostasis IGI
IGI: Inferred from genetic interaction
16075058 GOA
Cellular Component GO Annotation Evidence References Source
part of plasma membrane protein complex IDA
IDA: Inferred from direct assay
18335997 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEO1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (65 - 147)

I-set

I-set: Immunoglobulin I-set domain (152 - 239)

I-set

I-set: Immunoglobulin I-set domain (250 - 337)

I-set

I-set: Immunoglobulin I-set domain (341 - 427)

fn3

fn3: Fibronectin type III domain (440 - 525)

fn3

fn3: Fibronectin type III domain (543 - 618)

fn3

fn3: Fibronectin type III domain (636 - 720)

fn3

fn3: Fibronectin type III domain (742 - 818)

fn3

fn3: Fibronectin type III domain (856 - 942)

fn3

fn3: Fibronectin type III domain (956 - 1044)

Neogenin_C

Neogenin_C: Neogenin C-terminus (1156 - 1461)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1461 a.a.
Protein Preferred Names Protein Names

neogenin

  • immunoglobulin superfamily DCC subclass member 2

Recombinant NEO1 Proteins

Cat. No. Product Name Accession Purity
HY-P701081 Neogenin Protein, Human (HEK293, hFc) Q92859-1 (A34-L1105) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Corneal Intraepithelial Neoplasm
Hemochromatosis Type 2

  • Juvenile Hemochromatosis

  • Juvenile Hereditary Hemochromatosis

  • Hfe2

  • Jhh

  • Hemochromatosis Juvenile

  • Iron Overload Disease Juvenile

  • Hemochromatosis, Juvenile

  • Hemochromatosis, Type 2

  • Hemochromatosis

  • Hemochromatosis, Type 1
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

  • DMSMFH

  • Bone Dysplasia With Medullary Fibrosarcoma

  • Bdmf

  • Bone Dysplasia With Malignant Fibrous Histiocytoma

  • Hardcastle Syndrome

  • Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome

  • Myopathy, Limb-Girdle, With Bone Fragility

  • Bone Dysplasia-Medullary Fibrosarcoma Syndrome

  • Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome

  • Dms-Mfh

  • Limb-Girdle Myopathy With Bone Fragility

  • Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1

  • Dysequilibrium Syndrome

  • CAMRQ1

  • Des

  • Cerebellar Ataxia, Intellectual Disability, And Dysequilibrium Syndrome 1

  • Cerebellar Hypoplasia, Vldlr-Associated

  • Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion 1

  • Cerebellar Ataxia, Mental Retardation And Dysequlibrium Syndrome

  • Uner Tan Syndrome

  • Vldlr Cerebellar Hypoplasia

  • Vldlrch

  • Vldlr-Associated Cerebellar Hypoplasia

  • Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 1

  • Cerebellar Ataxia, Congenital, And Mental Retardation, Autosomal Recessive

  • Camrq

  • Cerebellar Ataxia, Mental Retardation, Dysequilibrium Syndrome 1

  • Cerebellar Disorder, Nonprogressive, With Intellectual Disability

  • Cerebellar Hypoplasia, Vldlr Associated

  • Autosomal Recessive Cerebellar Ataxia With Mental Retardation

  • Autosomal Recessive Cerebellar Hypoplasia With Cerebral Gyral Simplification

  • Cerebellar Disorder, Nonprogressive, With Mental Retardation

  • Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion

  • Chmrq1

  • Des-Vldlr

  • Dysequilibrium Syndrome-Vldlr

  • Vldlr-Ch

  • Camrq Syndrome

  • Cerebellar Ataxia-Intellectual Disability-Dysequilibrium Syndrome Syndrome

  • Non-Progressive Cerebellar Ataxia-Intellectual Disability Syndrome

  • Uts

  • Cerebellar Hypoplasia Vldlr-Associated

  • Dialysis Disequilibrium Syndrome
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09209 NEO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22250 Neo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28772 Neo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NEO1 VGNC VGNC:32007
Rattus norvegicus NEO1 RGD RGD:619837
Felis catus NEO1 VGNC VGNC:80901
Macaca mulatta NEO1 VGNC VGNC:75314
Mus musculus NEO1 MGD MGI:1097159
Canis familiaris NEO1 VGNC VGNC:43745
Others NEO1 NCBI