Nefm - neurofilament, medium polypeptide Gene

Also Known as Nfm; NF-M; Nef3; NF160; NF165

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18040

Summary

Predicted to enable signaling receptor binding activity and toxic substance binding activity. Acts upstream of or within axo-dendritic transport; Cytoskeleton organization; and regulation of axon diameter. Located in several cellular components, including intermediate filament cytoskeleton; neuromuscular junction; and postsynaptic density. Is active in presynaptic intermediate filament Cytoskeleton. Is expressed in several structures, including alimentary system; branchial arch; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefm Products (1)

mRNA Protein Name
NM_008691.2 NP_032717.2 neurofilament medium polypeptide

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within axo-dendritic transport IMP
IMP: Inferred from mutant phenotype
10461886 MGI
acts upstream of or within intermediate filament bundle assembly IGI
IGI: Inferred from genetic interaction
10461886 MGI
acts upstream of or within intermediate filament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
14561875 MGI
acts upstream of or within microtubule cytoskeleton organization IGI
IGI: Inferred from genetic interaction
10461886 MGI
acts upstream of or within neurofilament cytoskeleton organization IGI
IGI: Inferred from genetic interaction
10461886 MGI
acts upstream of or within neurofilament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
9566972 MGI
acts upstream of or within regulation of axon diameter IMP
IMP: Inferred from mutant phenotype
9566972 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
8110465 MGI
located in neurofilament IDA
IDA: Inferred from direct assay
10221457 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
15713258 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21884692 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
is active in postsynaptic intermediate filament cytoskeleton IDA
IDA: Inferred from direct assay
25869803 MGI
is active in presynaptic intermediate filament cytoskeleton IDA
IDA: Inferred from direct assay
25869803 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurofilament medium polypeptide

  • 160 kDa neurofilament protein

  • neurofilament 3, medium

  • neurofilament protein M

  • neurofilament triplet M protein

  • neurofilament-M

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10971 Nef-M1 98.87% Unkown
HY-RS09185 NEFM Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nefm NCBI NCBI:4741