2. Gene
  3. Nefm - neurofilament, medium polypeptide Gene

Nefm - neurofilament, medium polypeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nfm; NF-M; Nef3; NF160; NF165

Gene ID: 18040 | Gene type: protein coding

About Nefm

Summary

Predicted to enable signaling receptor binding activity and toxic substance binding activity. Acts upstream of or within axo-dendritic transport; Cytoskeleton organization; and regulation of axon diameter. Located in several cellular components, including intermediate filament cytoskeleton; neuromuscular junction; and postsynaptic density. Is active in presynaptic intermediate filament Cytoskeleton. Is expressed in several structures, including alimentary system; branchial arch; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefm Products(1)

mRNA Protein Name
NM_008691.2 NP_032717.2 neurofilament medium polypeptide
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axo-dendritic transport IMP
IMP: Inferred from mutant phenotype
10461886 MGI
acts upstream of or within intermediate filament bundle assembly IGI
IGI: Inferred from genetic interaction
10461886 MGI
acts upstream of or within intermediate filament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
14561875 MGI
acts upstream of or within microtubule cytoskeleton organization IGI
IGI: Inferred from genetic interaction
10461886 MGI
acts upstream of or within neurofilament cytoskeleton organization IGI
IGI: Inferred from genetic interaction
10461886 MGI
acts upstream of or within neurofilament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
9566972 MGI
acts upstream of or within regulation of axon diameter IMP
IMP: Inferred from mutant phenotype
9566972 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
8110465 MGI
located in neurofilament IDA
IDA: Inferred from direct assay
10221457 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
15713258 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21884692 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
is active in postsynaptic intermediate filament cytoskeleton IDA
IDA: Inferred from direct assay
25869803 MGI
is active in presynaptic intermediate filament cytoskeleton IDA
IDA: Inferred from direct assay
25869803 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurofilament medium polypeptide

160 kDa neurofilament protein

neurofilament 3, medium

neurofilament protein M

neurofilament triplet M protein

neurofilament-M

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10971 Nef-M1 / Unkown
HY-RS09185 NEFM Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nefm NCBI NCBI:4741