Nhlh2 - nescient helix loop helix 2 Gene

Also Known as Hen2; NSCL2; Nscl-2; bHLHa34; 6230401I09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18072

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on apoptotic process; hypothalamus gonadotrophin-releasing hormone neuron development; and peripheral nervous system development. Acts upstream of or within several processes, including cell migration in hindbrain; male gonad development; and male mating behavior. Located in chromatin. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; head mesenchyme derived from neural crest; and sensory organ. Orthologous to human NHLH2 (nescient helix-loop-helix 2). [provided by Alliance of Genome Resources, Apr 2022]

Nhlh2 Products (1)

mRNA	Protein	Name
NM_178777.3	NP_848892.1	helix-loop-helix protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15470499	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15470499	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18356286	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18356286	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22169038	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive effect apoptotic process	IGI IGI: Inferred from genetic interaction	17573818	MGI
acts upstream of or within cell migration in hindbrain	IGI IGI: Inferred from genetic interaction	17573818	MGI
acts upstream of or within positive effect hypothalamus gonadotrophin-releasing hormone neuron development	IMP IMP: Inferred from mutant phenotype	23785158	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	9090387	MGI
acts upstream of or within male mating behavior	IMP IMP: Inferred from mutant phenotype	9090387	MGI
acts upstream of or within ovulation cycle	IMP IMP: Inferred from mutant phenotype	15465527	MGI
acts upstream of or within positive effect peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	19436734	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15470499	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	18356286	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
helix-loop-helix protein 2	HEN-2

Nhlh2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Nhlh2	Q64221	Sirt1	Mus musculus	Q923E4	Anti Bait CoIP	22169038

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09285	NHLH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nhlh2	NCBI	NCBI:4808