Nkx3-1 - NK3 homeobox 1 Gene

Mus musculus

Also known as Bax; NKX3A; NKX3.1; Nkx-3.1; bagpipe

Gene ID: 18095 | Gene type: protein coding

About Nkx3-1

Summary

Enables several functions, including DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and MADS box domain binding activity. Involved in protein kinase B signaling; regulation of transcription, DNA-templated; and response to testosterone. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and negative regulation of epithelial cell proliferation involved in prostate gland development. Located in nucleus. Is expressed in several structures, including arterial system; central nervous system; genitourinary system; paraxial mesenchyme; and tooth. Used to study prostate Cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human NKX3-1 (NK3 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Nkx3-1 Products(2)

mRNA	Protein	Name
NM_010921.3	NP_035051.1	homeobox protein Nkx-3.1
NM_010921.3	NP_035051.1	homeobox protein Nkx-3.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10993896	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10993896	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18296735	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18296735	MGI
enables MADS box domain binding	IDA IDA: Inferred from direct assay	18296735	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18816836	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9142502	MGI
enables transcription factor binding	IDA IDA: Inferred from direct assay	10993896	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	10215624	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	11002344	MGI
involved in dorsal aorta development	IEP IEP: Inferred from expression pattern	9142502	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11002344	MGI
acts upstream of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	11002344	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	10906459	MGI
involved in heart development	IEP IEP: Inferred from expression pattern	9621431	MGI
involved in male gonad development	IEP IEP: Inferred from expression pattern	9142502	MGI
involved in metanephros development	IEP IEP: Inferred from expression pattern	9142502	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	19258508	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11002344	MGI
acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	11002344	MGI
acts upstream of or within negative regulation of insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	19258508	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19597465	MGI
involved in pharyngeal system development	IEP IEP: Inferred from expression pattern	9621431	MGI
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18296735	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10993896	MGI
involved in prostate gland development	IEP IEP: Inferred from expression pattern	9142502	MGI
involved in response to testosterone	IMP IMP: Inferred from mutant phenotype	9142502	MGI
acts upstream of or within salivary gland development	IMP IMP: Inferred from mutant phenotype	10906459	MGI
involved in somitogenesis	IEP IEP: Inferred from expression pattern	9621431	MGI
involved in urogenital system development	IEP IEP: Inferred from expression pattern	9142502	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15987773	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Nkx-3.1

Drosophila NK-3 transcription factor, locus 1	NK-3 transcription factor, locus 1
homeobox protein NK-3 homolog A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09333	NKX3-1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkx3-1	NCBI	NCBI:4824

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