Nkx3-1 - NK3 homeobox 1 Gene

Also Known as Bax; NKX3A; NKX3.1; Nkx-3.1; bagpipe

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18095

Summary

Enables several functions, including DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and MADS box domain binding activity. Involved in protein kinase B signaling; regulation of transcription, DNA-templated; and response to testosterone. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and negative regulation of epithelial cell proliferation involved in prostate gland development. Located in nucleus. Is expressed in several structures, including arterial system; central nervous system; genitourinary system; paraxial mesenchyme; and tooth. Used to study prostate Cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human NKX3-1 (NK3 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Nkx3-1 Products (2)

mRNA Protein Name
NM_010921.3 NP_035051.1 homeobox protein Nkx-3.1
NM_010921.3 NP_035051.1 homeobox protein Nkx-3.1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
10993896 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10993896 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
18296735 MGI
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
18296735 MGI
enables MADS box domain binding IDA
IDA: Inferred from direct assay
18296735 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18816836 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9142502 MGI
enables transcription factor binding IDA
IDA: Inferred from direct assay
10993896 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
10215624 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
11002344 MGI
involved in dorsal aorta development IEP
IEP: Inferred from expression pattern
9142502 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11002344 MGI
acts upstream of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
11002344 MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
10906459 MGI
involved in heart development IEP
IEP: Inferred from expression pattern
9621431 MGI
involved in male gonad development IEP
IEP: Inferred from expression pattern
9142502 MGI
involved in metanephros development IEP
IEP: Inferred from expression pattern
9142502 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
19258508 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11002344 MGI
acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
11002344 MGI
acts upstream of or within negative regulation of insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
19258508 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19597465 MGI
involved in pharyngeal system development IEP
IEP: Inferred from expression pattern
9621431 MGI
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
18296735 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10993896 MGI
involved in prostate gland development IEP
IEP: Inferred from expression pattern
9142502 MGI
involved in response to testosterone IMP
IMP: Inferred from mutant phenotype
9142502 MGI
acts upstream of or within salivary gland development IMP
IMP: Inferred from mutant phenotype
10906459 MGI
involved in somitogenesis IEP
IEP: Inferred from expression pattern
9621431 MGI
involved in urogenital system development IEP
IEP: Inferred from expression pattern
9142502 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15987773 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-3.1

  • Drosophila NK-3 transcription factor, locus 1

  • NK-3 transcription factor, locus 1

  • homeobox protein NK-3 homolog A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09333 NKX3-1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx3-1 NCBI NCBI:4824