Nrtn - neurturin Gene

Also Known as NTN

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18188

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. Homozygous knockout mice for this gene exhibit defects in the development of the retina and enteric nervous system, and reduced cholinergic innervation of the heart and lacrimal glands. [provided by RefSeq, Aug 2016]

Nrtn Products (1)

mRNA Protein Name
NM_008738.3 NP_032764.1 neurturin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables growth factor activity IDA
IDA: Inferred from direct assay
8945474 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway IGI
IGI: Inferred from genetic interaction
9576965 MGI
involved in glial cell-derived neurotrophic factor receptor signaling pathway IDA
IDA: Inferred from direct assay
8945474 MGI
acts upstream of or within nerve development IMP
IMP: Inferred from mutant phenotype
10069332 MGI
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IDA
IDA: Inferred from direct assay
8945474 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurturin

Recombinant Nrtn Proteins

Cat. No. Product Name Accession Purity
HY-P700224AF Animal-Free Neurturin Protein, Mouse (His) P97463.1 (P96-V195) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09582 NRTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18488 Nrtn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24970 Nrtn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nrtn NCBI NCBI:4902