Nthl1 - nth (endonuclease III)-like 1 (E.coli) Gene

Also Known as Nth1; Octs3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18207

Summary

Enables DNA N-glycosylase activity and DNA-(apurinic or apyrimidinic site) Endonuclease activity. Involved in nucleotide-excision repair, DNA incision, 5'-to lesion. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nthl1 Products (2)

mRNA Protein Name
NM_001357615.1 NP_001344544.1 endonuclease III-like protein 1 isoform 2
NM_008743.2 NP_032769.2 endonuclease III-like protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
9743625 MGI
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
IDA: Inferred from direct assay
9743625 MGI
Biological Process GO Annotation Evidence References Source
involved in nucleotide-excision repair IDA
IDA: Inferred from direct assay
9743625 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
12531031 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12531031 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endonuclease III-like protein 1

  • DNA glycoslyase/AP lyase

  • DNA glycosylase/AP lyase

  • bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase

  • bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase

  • thymine glycol DNA glycosylase/AP lyase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184013 SU0617 Inhibitor / Unkown
HY-RS09618 NTHL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nthl1 NCBI NCBI:4913