SU0617
SU0617 is a selective SMUG1 inhibitor with a human IC50 of 1.5 μM. SU0617 inhibits base excision repair activity of SMUG1, including excision of modified and damaged pyrimidines from DNA. SU0617 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- Formula: C21H15ClN4OS
- Molecular Weight:406.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
SU0617 (1-10 μM; 10-25 min) potently inhibits recombinant human SMUG1 with an IC50 of 1.5 μM[1].
SU0617 (1-10 μM) shows selective inhibition of recombinant human SMUG1 over bacterial UDG[1].
SU0617 (5 μM; 3 h) causes near-complete inhibition of recombinant human SMUG1-mediated DNA base excision[1].
SU0617 (48 h) exhibits minimal cytotoxicity in Hs578T and BT549 human breast cancer cell lines after 48 h of incubation, with an IC50 above 10 μM in both lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 406.89
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Formula C21H15ClN4OS
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SMILES
ClC1=CC=C(C2=CSC(NC3=CC=C(NC(C4=CC=CN=C4)=O)C=C3)=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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