2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. SU0617

SU0617 is a selective SMUG1 inhibitor with a human IC50 of 1.5 μM. SU0617 inhibits base excision repair activity of SMUG1, including excision of modified and damaged pyrimidines from DNA. SU0617 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

SU0617

SU0617 Chemical Structure

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SU0617 Related Antibodies

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Description

SU0617 is a selective SMUG1 inhibitor with a human IC50 of 1.5 μM. SU0617 inhibits base excision repair activity of SMUG1, including excision of modified and damaged pyrimidines from DNA. SU0617 can be used for the research of breast cancer[1].

In Vitro

SU0617 (1-10 μM; 10-25 min) potently inhibits recombinant human SMUG1 with an IC50 of 1.5 μM[1].
SU0617 (1-10 μM) shows selective inhibition of recombinant human SMUG1 over bacterial UDG[1].
SU0617 (5 μM; 3 h) causes near-complete inhibition of recombinant human SMUG1-mediated DNA base excision[1].
SU0617 (48 h) exhibits minimal cytotoxicity in Hs578T and BT549 human breast cancer cell lines after 48 h of incubation, with an IC50 above 10 μM in both lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SU0617 Related Antibodies
Molecular Weight

406.89

Formula

C21H15ClN4OS
SMILES

ClC1=CC=C(C2=CSC(NC3=CC=C(NC(C4=CC=CN=C4)=O)C=C3)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SU0617 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SU0617SU 0617SU-0617DNA/RNA Synthesisbase excision repairDNABT549pyrimidinesHs578Tsphingosine kinasesSMUG1NTHL1bacterial UDGbreast cancerInhibitorinhibitorinhibit

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