Bloc1s6 - biogenesis of lysosomal organelles complex-1, subunit 6, pallidin Gene

Also Known as pa; Hps9; Pldn; BLOC-1; Stx13bp1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18457

Summary

Predicted to enable actin filament binding activity and protein homodimerization activity. Involved in several processes, including cellular amino acid metabolic process; limbic system development; and vesicle organization. Acts upstream of or within several processes, including melanocyte differentiation; positive regulation of natural killer cell activation; and secretion of lysosomal Enzymes. Located in ciliary basal body and endosome. Part of BLOC-1 complex. Is expressed in brain; spinal cord; and thoracic ganglion. Used to study Hermansky-Pudlak syndrome 9; platelet storage pool deficiency; and pulmonary emphysema. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 9. Orthologous to human BLOC1S6 (biogenesis of lysosomal organelles complex 1 subunit 6). [provided by Alliance of Genome Resources, Apr 2022]

Bloc1s6 Products (1)

mRNA Protein Name
NM_019788.3 NP_062762.1 biogenesis of lysosome-related organelles complex 1 subunit 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
19116644 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12576321 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ATP metabolic process IMP
IMP: Inferred from mutant phenotype
12485443 MGI
acts upstream of or within actin filament bundle assembly IMP
IMP: Inferred from mutant phenotype
19116644 MGI
acts upstream of or within adenosine metabolic process IMP
IMP: Inferred from mutant phenotype
28701731 MGI
acts upstream of or within amino acid metabolic process IMP
IMP: Inferred from mutant phenotype
28701731 MGI
involved in anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
21998198 MGI
involved in anterograde synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
21998198 MGI
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
6696991 MGI
acts upstream of or within bradykinin biosynthetic process IMP
IMP: Inferred from mutant phenotype
12485443 MGI
acts upstream of or within cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
19116644 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
28576874 MGI
acts upstream of or within circadian sleep/wake cycle IMP
IMP: Inferred from mutant phenotype
30498428 MGI
acts upstream of or within dentate gyrus development IMP
IMP: Inferred from mutant phenotype
30498428 MGI
acts upstream of or within endothelium development IMP
IMP: Inferred from mutant phenotype
12485443 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
16439805 MGI
acts upstream of or within glutamate metabolic process IMP
IMP: Inferred from mutant phenotype
28701731 MGI
acts upstream of or within glutamine metabolic process IMP
IMP: Inferred from mutant phenotype
28701731 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
12485443 MGI
acts upstream of or within hypothalamus development IMP
IMP: Inferred from mutant phenotype
30498428 MGI
acts upstream of or within intracellular nitric oxide homeostasis IMP
IMP: Inferred from mutant phenotype
12485443 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
28576874 MGI
acts upstream of or within lipid homeostasis IMP
IMP: Inferred from mutant phenotype
30710063 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
30710063 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
16439805 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
16439805 MGI
acts upstream of or within melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
2379821 MGI
acts upstream of or within membrane fusion IPI
IPI: Inferred from physical interaction
10610180 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
26294018 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
19381131 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
19546860 MGI
acts upstream of or within phospholipid metabolic process IMP
IMP: Inferred from mutant phenotype
28701731 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
2379821 MGI
acts upstream of or within positive regulation of natural killer cell activation IMP
IMP: Inferred from mutant phenotype
7089489 MGI
acts upstream of or within protein secretion IMP
IMP: Inferred from mutant phenotype
29074498 MGI
acts upstream of or within protein targeting IMP
IMP: Inferred from mutant phenotype
16760431 MGI
acts upstream of or within protein transmembrane transport IMP
IMP: Inferred from mutant phenotype
28576874 MGI
acts upstream of or within respiratory system process IMP
IMP: Inferred from mutant phenotype
19381131 MGI
acts upstream of or within response to acetylcholine IMP
IMP: Inferred from mutant phenotype
12485443 MGI
acts upstream of or within response to activity IMP
IMP: Inferred from mutant phenotype
19381131 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
12485443 MGI
acts upstream of or within secretion of lysosomal enzymes IMP
IMP: Inferred from mutant phenotype
7089489 MGI
acts upstream of or within vasodilation IMP
IMP: Inferred from mutant phenotype
12485443 MGI
Cellular Component GO Annotation Evidence References Source
part of BLOC-1 complex IDA
IDA: Inferred from direct assay
12576321 MGI
is active in cell-cell contact zone IDA
IDA: Inferred from direct assay
19116644 MGI
is active in contractile ring IDA
IDA: Inferred from direct assay
19116644 MGI
located in endosome IDA
IDA: Inferred from direct assay
10610180 MGI
part of filamentous actin IDA
IDA: Inferred from direct assay
19116644 MGI
is active in focal adhesion IDA
IDA: Inferred from direct assay
19116644 MGI
is active in microvesicle IDA
IDA: Inferred from direct assay
16760431 MGI
is active in ruffle IDA
IDA: Inferred from direct assay
19116644 MGI
is active in stress fiber IDA
IDA: Inferred from direct assay
19116644 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

biogenesis of lysosome-related organelles complex 1 subunit 6

  • BLOC-1 subunit 6

  • biogenesis of organelles complex-1, subunit 6, pallidin

  • pallid protein

  • pallidin

  • syntaxin 13 binding protein 1

  • syntaxin 13-interacting protein pallid

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01525 BLOC1S6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bloc1s6 NCBI NCBI:26258