Pcsk5 - proprotein convertase subtilisin/kexin type 5 Gene

Mus musculus

Also known as PC5; PC6; SPC6; b2b585Clo; b2b1549Clo

Gene ID: 18552 | Gene type: protein coding

About Pcsk5

Summary

This gene encodes a subtilisin-like proprotein convertase that mediates posttranslational endoproteolytic processing of various proprotein substrates traversing the secretory pathway. The encoded protein is an inactive zymogen that undergoes autoproteolytic processing in the endoplasmic reticulum and the Golgi network to generate an active enzyme. Mice lacking the encoded protein die at an early embryonic stage. Conditional inactivation this gene in the epiblast but not in the extraembryonic tissue bypasses embryonic lethality but results in death at birth. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Pcsk5 Products(2)

mRNA	Protein	Name
NM_001163144.1	NP_001156616.1	proprotein convertase subtilisin/kexin type 5 isoform 2 precursor
NM_001190483.2	NP_001177412.1	proprotein convertase subtilisin/kexin type 5 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	9242664	MGI
enables peptide binding	IDA IDA: Inferred from direct assay	8940009	MGI
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	8468318	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	18519639	MGI
acts upstream of or within cardiac septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in cytokine precursor processing	IDA IDA: Inferred from direct assay	18519639	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in embryo implantation	IMP IMP: Inferred from mutant phenotype	15601911	MGI
involved in embryonic digestive tract development	IMP IMP: Inferred from mutant phenotype	18519639	MGI
involved in embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	18519639	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	18519639	MGI
involved in kidney development	IMP IMP: Inferred from mutant phenotype	18519639	MGI
involved in limb morphogenesis	IMP IMP: Inferred from mutant phenotype	18519639	MGI
involved in peptide biosynthetic process	IDA IDA: Inferred from direct assay	8468318	MGI
involved in peptide hormone processing	IDA IDA: Inferred from direct assay	8468318	MGI
acts upstream of or within protein processing	IDA IDA: Inferred from direct assay	21147780	MGI
involved in protein processing	IDA IDA: Inferred from direct assay	8468318	MGI
involved in respiratory tube development	IMP IMP: Inferred from mutant phenotype	18519639	MGI
involved in viral life cycle	IDA IDA: Inferred from direct assay	8940009	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8940009	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proprotein convertase subtilisin/kexin type 5

proprotein convertase 5	proprotein convertase 6
proprotein convertase PC5	subtilisin-like proprotein convertase 6
subtilisin/kexin-like protease PC5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10174	PCSK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pcsk5	NCBI	NCBI:5125

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