Pcsk5 - proprotein convertase subtilisin/kexin type 5 Gene

Also Known as PC5; PC6; SPC6; b2b585Clo; b2b1549Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18552

Summary

This gene encodes a subtilisin-like proprotein convertase that mediates posttranslational endoproteolytic processing of various proprotein substrates traversing the secretory pathway. The encoded protein is an inactive zymogen that undergoes autoproteolytic processing in the endoplasmic reticulum and the Golgi network to generate an active enzyme. Mice lacking the encoded protein die at an early embryonic stage. Conditional inactivation this gene in the epiblast but not in the extraembryonic tissue bypasses embryonic lethality but results in death at birth. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Pcsk5 Products (2)

mRNA Protein Name
NM_001163144.1 NP_001156616.1 proprotein convertase subtilisin/kexin type 5 isoform 2 precursor
NM_001190483.2 NP_001177412.1 proprotein convertase subtilisin/kexin type 5 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
9242664 MGI
enables peptide binding IDA
IDA: Inferred from direct assay
8940009 MGI
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
8468318 MGI
Biological Process GO Annotation Evidence References Source
involved in anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
18519639 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in cytokine precursor processing IDA
IDA: Inferred from direct assay
18519639 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in embryo implantation IMP
IMP: Inferred from mutant phenotype
15601911 MGI
involved in embryonic digestive tract development IMP
IMP: Inferred from mutant phenotype
18519639 MGI
involved in embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
18519639 MGI
involved in heart development IMP
IMP: Inferred from mutant phenotype
18519639 MGI
involved in kidney development IMP
IMP: Inferred from mutant phenotype
18519639 MGI
involved in limb morphogenesis IMP
IMP: Inferred from mutant phenotype
18519639 MGI
involved in peptide biosynthetic process IDA
IDA: Inferred from direct assay
8468318 MGI
involved in peptide hormone processing IDA
IDA: Inferred from direct assay
8468318 MGI
acts upstream of or within protein processing IDA
IDA: Inferred from direct assay
21147780 MGI
involved in protein processing IDA
IDA: Inferred from direct assay
8468318 MGI
involved in respiratory tube development IMP
IMP: Inferred from mutant phenotype
18519639 MGI
involved in viral life cycle IDA
IDA: Inferred from direct assay
8940009 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
8940009 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proprotein convertase subtilisin/kexin type 5

  • proprotein convertase 5

  • proprotein convertase 6

  • proprotein convertase PC5

  • subtilisin-like proprotein convertase 6

  • subtilisin/kexin-like protease PC5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10174 PCSK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcsk5 NCBI NCBI:5125