Per3 - period circadian clock 3 Gene

Also Known as mPer3; 2810049O06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18628

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Per3 Products (3)

mRNA Protein Name
NM_001289877.1 NP_001276806.1 period circadian protein homolog 3 isoform 1
NM_001289878.1 NP_001276807.1 period circadian protein homolog 3 isoform 3
NM_011067.3 NP_035197.2 period circadian protein homolog 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables kinase binding IPI
IPI: Inferred from physical interaction
15917222 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9856466 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
15917222 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within circadian rhythm IDA
IDA: Inferred from direct assay
12843397 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9989497 MGI
involved in regulation of circadian sleep/wake cycle, sleep IMP
IMP: Inferred from mutant phenotype
21957163 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

period circadian protein homolog 3

  • circadian clock protein PERIOD 3

  • period homolog 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135629 PF-5236216 Inhibitor / Unkown
HY-RS10333 PER3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Per3 NCBI NCBI:8863