PER3 - period circadian regulator 3 Gene

Also Known as GIG13; FASPS3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8863

About PER3

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:7,784,291-7,845,177 (from NCBI)

This gene has 9 transcripts (splice variants), 178 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 14.6), fat (RPKM 11.2) and 24 other tissues.

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]

PER3 Products (7)

mRNA Protein Name
NM_001289861.2 NP_001276790.1 period circadian protein homolog 3 isoform 2
NM_001289862.2 NP_001276791.1 period circadian protein homolog 3 isoform 1
NM_001289863.3 NP_001276792.1 period circadian protein homolog 3 isoform 3
NM_001289864.3 NP_001276793.1 period circadian protein homolog 3 isoform 5
NM_001377275.1 NP_001364204.1 period circadian protein homolog 3 isoform 1
NM_001377276.1 NP_001364205.1 period circadian protein homolog 3 isoform 6
NM_016831.4 NP_058515.1 period circadian protein homolog 3 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21070773 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
26903630 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
26903630 GOA
involved in regulation of circadian sleep/wake cycle, sleep IMP
IMP: Inferred from mutant phenotype
17346965 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26903630 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26903630 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

period circadian protein homolog 3

  • cell growth-inhibiting gene 13 protein

PER3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PER3 P56645 CHEK2 Homo sapiens O96017
Anti Tag CoIP
21070773
Intra
PER3 P56645 CHEK2 Homo sapiens O96017
Anti Bait CoIP
21070773
Intra
PER3 P56645 PER1 Homo sapiens O15534
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Advanced Sleep Phase Syndrome, Familial, 3

  • Advanced Sleep Phase Syndrome 3

  • FASPS3

  • Familial Advanced Sleep Phase Syndrome 3

  • Sleep Phase Syndrome, Advanced, Familial, Type 3
Advanced Sleep Phase Syndrome

  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial
Delayed Sleep Phase Disorder

  • Delayed Sleep Phase Syndrome

  • Delayed Sleep Phase Syndrome, Susceptibility To

  • DSPD

  • Delayed Sleep Phase Disorder, Susceptibility To

  • DSPS

  • Sleep Phase, Delayed, Disorder

  • Sleep Phase Syndrome, Delayed, Susceptibility To
Bile Duct Cystadenoma

  • Cystadenoma Of The Bile Duct
Mood Disorder

  • Mood Disorders

  • Episodic Mood Disorder
Gum Cancer

  • Malignant Neoplasm Of Gum

  • Malignant Tumor Of Gum

  • Malignant Gingival Tumor

  • Malignant Neoplasm Of Other Sites Of Gum

  • Malignant Tumour Of Gingiva
Sleep Disorder

  • Sleep Disorders

  • Non-Organic Sleep Disorder
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Periodic Limb Movement Disorder

  • Nocturnal Myoclonus Syndrome

  • Nocturnal Myoclonus
Chromosome 1p36 Deletion Syndrome

  • 1p36 Deletion Syndrome

  • Deletion 1p36

  • Monosomy 1p36

  • Subtelomeric 1p36 Deletion

  • Monosomy 1p36 Syndrome

  • Distal Monosomy 1p36

  • Del(1)(P36)

  • Deletion 1pter

  • Monosomy 1pter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135629 PF-5236216 Inhibitor / Unkown
HY-RS10333 PER3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PER3 RGD RGD:621581
Macaca mulatta PER3 VGNC VGNC:100031
Canis familiaris PER3 VGNC VGNC:44422
Mus musculus PER3 MGD MGI:1277134
Others PER3 NCBI