PER1 - period circadian regulator 1 Gene
Also Known as PER; hPER; RIGUI
Species: Homo sapiens
About PER1
This gene has 19 transcripts (splice variants), 212 orthologues, 2 paralogues and is associated with 70 phenotypes. Ubiquitous expression in bone marrow (RPKM 31.1), ovary (RPKM 28.6) and 25 other tissues.
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014]
PER1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002616.3 | NP_002607.2 | period circadian protein homolog 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables E-box binding |
IDA
IDA: Inferred from direct assay
|
18411297 | GOA |
| enables RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
18411297 | GOA |
| enables kinase binding |
IPI
IPI: Inferred from physical interaction
|
15917222 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
23503662 | GOA |
| enables ubiquitin protein ligase binding |
IPI
IPI: Inferred from physical interaction
|
15917222 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in circadian regulation of gene expression |
IDA
IDA: Inferred from direct assay
|
18411297 | GOA |
| involved in circadian rhythm |
IEP
IEP: Inferred from expression pattern
|
14645221 | GOA |
| involved in regulation of hair cycle |
IMP
IMP: Inferred from mutant phenotype
|
24005054 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
24005054 | GOA |
PER1 Protein Structure
PAS_11: PAS domain (360 - 461)
Period_C: Period protein 2/3C-terminal region (1032 - 1214)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1200
- 1290 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
period circadian protein homolog 1 |
|
PER1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PER1 | O15534 | FKBP1A | Homo sapiens | Q0VDC6 | 32814053 | |
|
Intra
|
PER1 | O15534 | FKBP1A | Homo sapiens | Q0VDC6 | 32814053 | |
|
Intra
|
PER1 | O15534 | FKBP1A | Homo sapiens | Q0VDC6 | 32814053 | |
|
Intra
|
PER1 | O15534 | SARS1 | Homo sapiens | P49591 | 32814053 | |
|
Intra
|
PER1 | O15534 | SARS1 | Homo sapiens | P49591 | 32814053 | |
|
Intra
|
PER1 | O15534 | SARS1 | Homo sapiens | P49591 | 32814053 | |
|
Intra
|
PER1 | O15534 | EIF2S3 | Homo sapiens | P41091 | 32814053 | |
|
Intra
|
PER1 | O15534 | EIF2S3 | Homo sapiens | P41091 | 32814053 | |
|
Intra
|
PER1 | O15534 | EIF2S3 | Homo sapiens | P41091 | 32814053 | |
|
Intra
|
PER1 | O15534 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
PER1 | O15534 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
PER1 | O15534 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
PER1 | O15534 | KIF1B | Homo sapiens | O60333-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | KIF1B | Homo sapiens | O60333-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | KIF1B | Homo sapiens | O60333-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | BAG6 | Homo sapiens | P46379-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | BAG6 | Homo sapiens | P46379-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | BAG6 | Homo sapiens | P46379-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | PLP1 | Homo sapiens | P60201-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | PLP1 | Homo sapiens | P60201-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | PLP1 | Homo sapiens | P60201-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | APBB2 | Homo sapiens | Q92870-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | APBB2 | Homo sapiens | Q92870-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | APBB2 | Homo sapiens | Q92870-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | ERN1 | Homo sapiens | O75460-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | ERN1 | Homo sapiens | O75460-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | ERN1 | Homo sapiens | O75460-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | ST13 | Homo sapiens | Q9P1I4 | 32814053 | |
|
Intra
|
PER1 | O15534 | ST13 | Homo sapiens | Q9P1I4 | 32814053 | |
|
Intra
|
PER1 | O15534 | ST13 | Homo sapiens | Q9P1I4 | 32814053 | |
|
Intra
|
PER1 | O15534 | RAN | Homo sapiens | P62826 | 32814053 | |
|
Intra
|
PER1 | O15534 | RAN | Homo sapiens | P62826 | 32814053 | |
|
Intra
|
PER1 | O15534 | RAN | Homo sapiens | P62826 | 32814053 | |
|
Intra
|
PER1 | O15534 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
PER1 | O15534 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
PER1 | O15534 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
PER1 | O15534 | HRAS | Homo sapiens | P01112 | 32814053 | |
|
Intra
|
PER1 | O15534 | HRAS | Homo sapiens | P01112 | 32814053 | |
|
Intra
|
PER1 | O15534 | HRAS | Homo sapiens | P01112 | 32814053 | |
|
Intra
|
PER1 | O15534 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
PER1 | O15534 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
PER1 | O15534 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
PER1 | O15534 | HSPB1 | Homo sapiens | P04792 | 32814053 | |
|
Intra
|
PER1 | O15534 | HSPB1 | Homo sapiens | P04792 | 32814053 | |
|
Intra
|
PER1 | O15534 | HSPB1 | Homo sapiens | P04792 | 32814053 | |
|
Intra
|
PER1 | O15534 | HSPA2 | Homo sapiens | P54652 | 32814053 | |
|
Intra
|
PER1 | O15534 | HSPA2 | Homo sapiens | P54652 | 32814053 | |
|
Intra
|
PER1 | O15534 | HSPA2 | Homo sapiens | P54652 | 32814053 | |
|
Intra
|
PER1 | O15534 | CCT7 | Homo sapiens | Q99832 | 32814053 | |
|
Intra
|
PER1 | O15534 | CCT7 | Homo sapiens | Q99832 | 32814053 | |
|
Intra
|
PER1 | O15534 | CCT7 | Homo sapiens | Q99832 | 32814053 | |
|
Intra
|
PER1 | O15534 | NUPR1 | Homo sapiens | O60356 | 32814053 | |
|
Intra
|
PER1 | O15534 | NUPR1 | Homo sapiens | O60356 | 32814053 | |
|
Intra
|
PER1 | O15534 | NUPR1 | Homo sapiens | O60356 | 32814053 | |
|
Intra
|
PER1 | O15534 | P4HB | Homo sapiens | P07237 | 32814053 | |
|
Intra
|
PER1 | O15534 | P4HB | Homo sapiens | P07237 | 32814053 | |
|
Intra
|
PER1 | O15534 | P4HB | Homo sapiens | P07237 | 32814053 | |
|
Intra
|
PER1 | O15534 | PRPF40A | Homo sapiens | O75400-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | PRPF40A | Homo sapiens | O75400-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | PRPF40A | Homo sapiens | O75400-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | EEF1D | Homo sapiens | P29692-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | EEF1D | Homo sapiens | P29692-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | EEF1D | Homo sapiens | P29692-2 | 32814053 | |
|
Intra
|
PER1 | O15534 | CASP6 | Homo sapiens | P55212 | 32814053 | |
|
Intra
|
PER1 | O15534 | CASP6 | Homo sapiens | P55212 | 32814053 | |
|
Intra
|
PER1 | O15534 | CASP6 | Homo sapiens | P55212 | 32814053 | |
|
Intra
|
PER1 | O15534 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
PER1 | O15534 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
PER1 | O15534 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
PER1 | O15534 | CRY1 | Homo sapiens | Q16526 | 28514442 | |
|
Intra
|
PER1 | O15534 | CRY1 | Homo sapiens | Q16526 | 33961781 | |
|
Intra
|
PER1 | O15534 | UBQLN1 | Homo sapiens | Q9UMX0 | 32814053 | |
|
Intra
|
PER1 | O15534 | UBQLN1 | Homo sapiens | Q9UMX0 | 32814053 | |
|
Intra
|
PER1 | O15534 | UBQLN1 | Homo sapiens | Q9UMX0 | 32814053 | |
|
Intra
|
PER1 | O15534 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
PER1 | O15534 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
PER1 | O15534 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
PER1 | O15534 | GRN | Homo sapiens | P28799 | 32814053 | |
|
Intra
|
PER1 | O15534 | GRN | Homo sapiens | P28799 | 32814053 | |
|
Intra
|
PER1 | O15534 | GRN | Homo sapiens | P28799 | 32814053 | |
|
Intra
|
PER1 | O15534 | PRPS1 | Homo sapiens | P60891 | 32814053 | |
|
Intra
|
PER1 | O15534 | PRPS1 | Homo sapiens | P60891 | 32814053 | |
|
Intra
|
PER1 | O15534 | PRPS1 | Homo sapiens | P60891 | 32814053 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Advanced Sleep Phase Syndrome |
|
|
| Rem Sleep Behavior Disorder |
|
|
| Hypotrichosis 8 |
|
|
| Moebius Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | PER1 | VGNC | VGNC:44420 |
| Rattus norvegicus | PER1 | RGD | RGD:727863 |
| Bos taurus | PER1 | VGNC | VGNC:32748 |
| Mus musculus | PER1 | MGD | MGI:1098283 |
| Macaca mulatta | PER1 | VGNC | VGNC:75942 |
| Felis catus | PER1 | VGNC | VGNC:68787 |
| Others | PER1 | NCBI |