Phex - phosphate regulating endopeptidase homolog, X-linked Gene

Also Known as Gy; Hyp; PEX; HPDR; HPDR1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18675

Summary

Predicted to enable metalloendopeptidase activity. Acts upstream of or within bone mineralization; odontogenesis; and organophosphate metabolic process. Located in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Is expressed in several structures, including chondrocranium; epidermis; limb; liver; and tooth. Used to study X-linked dominant hypophosphatemic rickets and otitis media. Human ortholog(s) of this gene implicated in X-linked dominant hypophosphatemic rickets. Orthologous to human PHEX (phosphate regulating endopeptidase homolog X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Phex Products (1)

mRNA Protein Name
NM_011077.2 NP_035207.1 phosphate-regulating neutral endopeptidase PHEX

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
15843468 MGI
acts upstream of or within odontogenesis IMP
IMP: Inferred from mutant phenotype
23174213 MGI
acts upstream of or within organophosphate metabolic process IMP
IMP: Inferred from mutant phenotype
15843468 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11811562 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
11811562 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11811562 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphate-regulating neutral endopeptidase PHEX

  • Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein)

  • X-linked hypophosphatemia protein

  • X-linked phosphate regulating endopeptidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0050 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester 96.38% Unkown
HY-RS10412 PHEX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phex NCBI NCBI:5251