Pik3c2a - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Gene

Also Known as Cpk-m; PI3KC2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18704

About Pik3c2a

Chromosome 7: 115,936,500-116,042,684 reverse strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 222 orthologues, 9 paralogues and is associated with 72 phenotypes. Ubiquitous expression in placenta adult (RPKM 5.5), limb E14.5 (RPKM 4.) and 25 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Acts upstream of or within several processes, including autophagosome organization; negative regulation of zinc ion transmembrane transport; and phosphatidylinositol-3-phosphate biosynthetic process. Predicted to be located in several cellular components, including clathrin-coated vesicle; nucleoplasm; and trans-Golgi network. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c2a Products (1)

mRNA Protein Name
NM_011083.2 NP_035213.2 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol-3-kinase activity IDA
IDA: Inferred from direct assay
8663140 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within autophagosome organization IGI
IGI: Inferred from genetic interaction
24098492 MGI
acts upstream of or within cellular response to starvation IGI
IGI: Inferred from genetic interaction
24098492 MGI
acts upstream of or within macroautophagy IGI
IGI: Inferred from genetic interaction
24098492 MGI
acts upstream of or within negative regulation of zinc ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
23823722 MGI
acts upstream of or within phosphatidylinositol-3-phosphate biosynthetic process IGI
IGI: Inferred from genetic interaction
24098492 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3c2a Protein Structure

PI3K_rbd

PI3K_rbd: pfam00794 (419 - 512)

C2A_PI3K_class_II

C2A_PI3K_class_II: cd04012 (676 - 848)

PI3Ka_II

PI3Ka_II: cd00869 (868 - 1037)

PI3Kc_C2_alpha

PI3Kc_C2_alpha: cd05176 (1042 - 1394)

PX_PI3K_C2_alpha

PX_PI3K_C2_alpha: cd07289 (1425 - 1533)

C2B_PI3K_class_II

C2B_PI3K_class_II: cd08381 (1559 - 1680)

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  • 1686 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

  • PI3K-C2-alpha

  • p170

  • phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide

  • phosphoinositide 3-kinase-C2-alpha

  • ptdIns-3-kinase C2 subunit alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112608 CHMFL-PI3KD-317 Inhibitor 98.04% Unkown
HY-RS10511 PIK3C2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10512 Pik3c2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10513 Pik3c2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3c2a NCBI NCBI:5286