Pirb - paired Ig-like receptor B Gene

Also Known as Gp91; LIR-3; PIR-B; Lilrb3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18733

Summary

Enables amyloid-beta binding activity and protein homodimerization activity. Involved in learning or memory; regulation of protein metabolic process; and regulation of synaptic plasticity. Acts upstream of or within several processes, including B cell homeostasis; B cell mediated immunity; and myeloid dendritic cell differentiation. Predicted to be located in cytoplasm; external side of plasma membrane; and extracellular space. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and ganglionic eminence. Orthologous to several human genes including LILRB5 (leukocyte immunoglobulin like receptor B5). [provided by Alliance of Genome Resources, Apr 2022]

Pirb Products (2)

mRNA Protein Name
NM_001357394.1 NP_001344323.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 2 precursor
NM_011095.2 NP_035225.2 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
24052308 MGI
enables amyloid-beta binding IMP
IMP: Inferred from mutant phenotype
24052308 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22660330 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
24052308 MGI
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
24052308 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell homeostasis IMP
IMP: Inferred from mutant phenotype
12021780 MGI
acts upstream of or within B cell mediated immunity IMP
IMP: Inferred from mutant phenotype
12021780 MGI
acts upstream of or within cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12021780 MGI
involved in learning or memory IGI
IGI: Inferred from genetic interaction
24052308 MGI
acts upstream of or within myeloid dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
12021780 MGI
involved in negative regulation of protein metabolic process IGI
IGI: Inferred from genetic interaction
24052308 MGI
involved in positive regulation of long-term synaptic depression IGI
IGI: Inferred from genetic interaction
24052308 MGI
involved in regulation of long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
24052308 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 3

  • cell-surface glycoprotein p91

  • leukocyte immunoglobulin-like receptor 3

  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3

  • paired immunoglobulin-like receptor B

Pirb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Lilrb3 P97484 Ptpn11 Mus musculus P35235
Anti Bait CoIP
24052308
Intra
Lilrb3 P97484 Ptpn11 Mus musculus P35235
Anti Bait CoIP
22660330
Cross
Lilrb3 P97484 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092
IF
24052308
Cross
Lilrb3 P97484 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092
Anti Bait CoIP
24052308
Cross
Lilrb3 P97484 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092
Affinity Chrom
24052308
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Pirb Proteins

Cat. No. Product Name Accession Purity
HY-P77064 LILRB3/CD85a Protein, Mouse (HEK293, His, solution) AAC53219 (S25-Y640) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07651 LILRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07653 LILRB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24023 Lilrb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown