Plcb3 - phospholipase C, beta 3 Gene

Also Known as mKIAA4098

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18797

Summary

Predicted to enable Calmodulin binding activity and phosphatidylinositol Phospholipase C activity. Predicted to be involved in several processes, including inositol trisphosphate metabolic process; phosphatidylinositol catabolic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within regulation of systemic arterial blood pressure. Located in postsynaptic cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (Phospholipase C beta 3). [provided by Alliance of Genome Resources, Apr 2022]

Plcb3 Products (2)

mRNA Protein Name
NM_001290349.1 NP_001277278.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a
NM_008874.4 NP_032900.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol phospholipase C activity IDA
IDA: Inferred from direct assay
9188725 MGI
Biological Process GO Annotation Evidence References Source
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
20966218 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22728827 MGI
Cellular Component GO Annotation Evidence References Source
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
17298601 MGI
is active in postsynaptic cytosol IEP
IEP: Inferred from expression pattern
17298601 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

  • PLC-beta-3

  • phosphoinositide phospholipase C-beta-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10654 PLCB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plcb3 NCBI NCBI:5331