Pola2 - polymerase (DNA directed), alpha 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18969

Summary

Predicted to enable DNA-directed DNA Polymerase activity. Involved in DNA replication, synthesis of RNA primer. Acts upstream of or within DNA replication and protein import into nucleus. Located in nucleus. Part of alpha DNA polymerase:primase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human POLA2 (DNA Polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]

Pola2 Products (2)

mRNA Protein Name
NM_001164057.2 NP_001157529.1 DNA polymerase alpha subunit B isoform 2
NM_008893.4 NP_032919.2 DNA polymerase alpha subunit B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9584195 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA replication IDA
IDA: Inferred from direct assay
9584195 MGI
involved in DNA replication initiation IDA
IDA: Inferred from direct assay
10523676 MGI
involved in DNA replication, synthesis of primer IDA
IDA: Inferred from direct assay
8026492 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
9584195 MGI
Cellular Component GO Annotation Evidence References Source
part of alpha DNA polymerase:primase complex IDA
IDA: Inferred from direct assay
8026492 MGI
part of alpha DNA polymerase:primase complex IPI
IPI: Inferred from physical interaction
10523676 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9584195 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase alpha subunit B

  • DNA polymerase alpha 2, 68 kDa

  • DNA polymerase alpha 70 kDa subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E71047 DNA Polymerase Alpha, Human / Unkown
HY-RS10817 POLA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pola2 NCBI NCBI:23649