Pou3f3 - POU domain, class 3, transcription factor 3 Gene

Mus musculus

Also known as Brn1; Otf8; Brn-1; Skin1; HST011; urehr2

Gene ID: 18993 | Gene type: protein coding

About Pou3f3

Summary

Enables HMG box domain binding activity and sequence-specific DNA binding activity. Involved in several processes, including metanephric nephron epithelium development; negative regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including excretion; forebrain development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; phalanx; and sensory organ. Orthologous to human POU3F3 (POU class 3 homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Pou3f3 Products(1)

mRNA	Protein	Name
NM_008900.3	NP_032926.2	POU domain, class 3, transcription factor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15465489	MGI
enables HMG box domain binding	IPI IPI: Inferred from physical interaction	16582099	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11997177	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11997177	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cerebral cortex radially oriented cell migration	IGI IGI: Inferred from genetic interaction	12130536	MGI
acts upstream of or within chemical homeostasis	IMP IMP: Inferred from mutant phenotype	17264314	MGI
acts upstream of or within forebrain ventricular zone progenitor cell division	IGI IGI: Inferred from genetic interaction	12130536	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	12925600	MGI
involved in metanephric DCT cell differentiation	IMP IMP: Inferred from mutant phenotype	12925600	MGI
involved in metanephric ascending thin limb development	IMP IMP: Inferred from mutant phenotype	12925600	MGI
involved in metanephric loop of Henle development	IMP IMP: Inferred from mutant phenotype	12925600	MGI
involved in metanephric macula densa development	IMP IMP: Inferred from mutant phenotype	12925600	MGI
involved in metanephric thick ascending limb development	IMP IMP: Inferred from mutant phenotype	12925600	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11997177	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12925600	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12925600	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12925600	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17141158	MGI
acts upstream of or within urea transmembrane transport	IMP IMP: Inferred from mutant phenotype	17264314	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8663425	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

POU domain, class 3, transcription factor 3

OTF-8	brain-1
brain-specific homeobox/POU domain protein 1	oct-8
octamer-binding protein 8	octamer-binding transcription factor 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10902	POU3F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou3f3	NCBI	NCBI:5455

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