Pou3f3 - POU domain, class 3, transcription factor 3 Gene

Also Known as Brn1; Otf8; Brn-1; Skin1; HST011; urehr2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18993

Summary

Enables HMG box domain binding activity and sequence-specific DNA binding activity. Involved in several processes, including metanephric nephron epithelium development; negative regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including excretion; forebrain development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; phalanx; and sensory organ. Orthologous to human POU3F3 (POU class 3 homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Pou3f3 Products (1)

mRNA Protein Name
NM_008900.3 NP_032926.2 POU domain, class 3, transcription factor 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15465489 MGI
enables HMG box domain binding IPI
IPI: Inferred from physical interaction
16582099 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11997177 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11997177 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cerebral cortex radially oriented cell migration IGI
IGI: Inferred from genetic interaction
12130536 MGI
acts upstream of or within chemical homeostasis IMP
IMP: Inferred from mutant phenotype
17264314 MGI
acts upstream of or within forebrain ventricular zone progenitor cell division IGI
IGI: Inferred from genetic interaction
12130536 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
12925600 MGI
involved in metanephric DCT cell differentiation IMP
IMP: Inferred from mutant phenotype
12925600 MGI
involved in metanephric ascending thin limb development IMP
IMP: Inferred from mutant phenotype
12925600 MGI
involved in metanephric loop of Henle development IMP
IMP: Inferred from mutant phenotype
12925600 MGI
involved in metanephric macula densa development IMP
IMP: Inferred from mutant phenotype
12925600 MGI
involved in metanephric thick ascending limb development IMP
IMP: Inferred from mutant phenotype
12925600 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11997177 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12925600 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12925600 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12925600 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17141158 MGI
acts upstream of or within urea transmembrane transport IMP
IMP: Inferred from mutant phenotype
17264314 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8663425 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

POU domain, class 3, transcription factor 3

  • OTF-8

  • brain-1

  • brain-specific homeobox/POU domain protein 1

  • oct-8

  • octamer-binding protein 8

  • octamer-binding transcription factor 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10902 POU3F3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pou3f3 NCBI NCBI:5455