POU3F3 - POU class 3 homeobox 3 Gene

Also Known as BRN1; OTF8; oct-8; SNIBFIS; brain-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5455

About POU3F3

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:104,854,115-104,858,574 (from NCBI)

This gene has 2 transcripts (splice variants), 86 orthologues, 17 paralogues and is associated with 2 phenotypes.

Summary

This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]

POU3F3 Products (1)

mRNA Protein Name
NM_006236.3 NP_006227.1 POU domain, class 3, transcription factor 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
31303265 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
31303265 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
31303265 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU3F3 Protein Structure

Pou

Pou: Pou domain - N-terminal to homeobox domain (315 - 388)

Homeobox

Homeobox: Homeobox domain (407 - 463)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500 a.a.
Protein Preferred Names Protein Names

POU domain, class 3, transcription factor 3

  • brain-specific homeobox/POU domain protein 1

Related Diseases

Diseases Alias
Snijders Blok-Fisher Syndrome

  • SNIBFIS
Esophagus Squamous Cell Carcinoma

  • Esophageal Squamous Cell Carcinoma

  • Oesophagus Squamous Cell Carcinoma

  • Scc Of Esophagus

  • Scc Of Oesophagus

  • Squamous Cell Carcinoma Of The Esophagus

  • Escc

  • Esophageal Epidermoid Carcinoma

  • Squamous Cell Esophageal Cancer

  • Squamous Cell Carcinoma Of Esophagus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10902 POU3F3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus POU3F3 VGNC VGNC:106872
Mus musculus POU3F3 MGD MGI:102564
Rattus norvegicus POU3F3 RGD RGD:619768
Others POU3F3 NCBI