Plpp1 - phospholipid phosphatase 1 Gene

Mus musculus

Also known as LPP1; mPAP; Hic53; LPP-1; PAP2a; Hpic53; PAP-2a; Ppap2a; PAP2-alpha

Gene ID: 19012 | Gene type: protein coding

About Plpp1

Summary

Enables diacylglycerol diphosphate Phosphatase activity; lipid Phosphatase activity; and phosphatidate Phosphatase activity. Involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and sphingolipid metabolic process. Located in caveola. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human PLPP1 (phospholipid Phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Plpp1 Products(2)

mRNA	Protein	Name
NM_008247.3	NP_032273.1	phospholipid phosphatase 1 isoform 1
NM_008903.2	NP_032929.1	phospholipid phosphatase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ceramide-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	10359651	MGI
enables diacylglycerol diphosphate phosphatase activity	IDA IDA: Inferred from direct assay	10359651	MGI
enables diacylglycerol diphosphate phosphatase activity	IMP IMP: Inferred from mutant phenotype	19215222	MGI
enables lipid phosphatase activity	IDA IDA: Inferred from direct assay	15461590	MGI
enables phosphatidate phosphatase activity	IDA IDA: Inferred from direct assay	8702556	MGI
enables phosphatidate phosphatase activity	IMP IMP: Inferred from mutant phenotype	19215222	MGI
enables sphingosine-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	10359651	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	10359651	MGI
involved in phospholipid dephosphorylation	IDA IDA: Inferred from direct assay	10359651	MGI
involved in phospholipid dephosphorylation	IMP IMP: Inferred from mutant phenotype	19215222	MGI
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	10359651	MGI
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	10359651	MGI
involved in sphingosine metabolic process	IDA IDA: Inferred from direct assay	10359651	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	11535125	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	19215222	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipid phosphatase 1

35 kDa PAP	hydrogen peroxide inducible protein 53
lipid phosphate phosphohydrolase 1	phosphatidate phosphohydrolase type 2a
phosphatidic acid phosphatase 2a	phosphatidic acid phosphatase type 2A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10734	PLPP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plpp1	NCBI	NCBI:8611

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