PLPP1 - phospholipid phosphatase 1 Gene

Also Known as LPP1; PAP2; LLP1a; PAP-2a; PPAP2A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8611

About PLPP1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,424,854-55,534,964 (from NCBI)

This gene has 6 transcripts (splice variants), 286 orthologues and 9 paralogues. Broad expression in prostate (RPKM 96.2), gall bladder (RPKM 74.3) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in Phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

PLPP1 Products (2)

mRNA Protein Name
NM_003711.4 NP_003702.2 phospholipid phosphatase 1 isoform 1
NM_176895.3 NP_795714.1 phospholipid phosphatase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ceramide-1-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
9705349 GOA
enables lipid phosphatase activity IDA
IDA: Inferred from direct assay
15461590 GOA
enables phosphatidate phosphatase activity IDA
IDA: Inferred from direct assay
9305923 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sphingosine-1-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
9705349 GOA
Biological Process GO Annotation Evidence References Source
involved in ceramide metabolic process IDA
IDA: Inferred from direct assay
9305923 GOA
involved in phospholipid dephosphorylation IDA
IDA: Inferred from direct assay
9305923 GOA
involved in phospholipid metabolic process IDA
IDA: Inferred from direct assay
9305923 GOA
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
15461590 GOA
involved in sphingosine metabolic process IDA
IDA: Inferred from direct assay
9705349 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
14527693 GOA
located in membrane IDA
IDA: Inferred from direct assay
9305923 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
17005594 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
9705349 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP1 Protein Structure

PAP2

PAP2: PAP2 superfamily (104 - 247)

  • 0
  • 100
  • 200
  • 284 a.a.
Protein Preferred Names Protein Names

phospholipid phosphatase 1

  • lipid phosphate phosphohydrolase 1a

PLPP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLPP1 O14494 PSEN1 Homo sapiens P49768-2
Validated Y2H
32814053
Intra
PLPP1 O14494 PSEN1 Homo sapiens P49768-2
Y2H Pooling
32814053
Intra
PLPP1 O14494 PSEN1 Homo sapiens P49768-2
Y2H Array
32814053
Intra
PLPP1 O14494 CASP1 Homo sapiens P29466-3
Y2H Array
32814053
Intra
PLPP1 O14494 CASP1 Homo sapiens P29466-3
Validated Y2H
32814053
Intra
PLPP1 O14494 CASP1 Homo sapiens P29466-3
Y2H Pooling
32814053
Intra
PLPP1 O14494 CAMK2A Homo sapiens Q9UQM7
Validated Y2H
32814053
Intra
PLPP1 O14494 CAMK2A Homo sapiens Q9UQM7
Y2H Array
32814053
Intra
PLPP1 O14494 CAMK2A Homo sapiens Q9UQM7
Y2H Pooling
32814053
Intra
PLPP1 O14494 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
PLPP1 O14494 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
PLPP1 O14494 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
PLPP1 O14494 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
PLPP1 O14494 GPR42 Homo sapiens O15529
Validated Y2H
32296183
Intra
PLPP1 O14494 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
PLPP1 O14494 PRKACA Homo sapiens P17612
Validated Y2H
32814053
Intra
PLPP1 O14494 PRKACA Homo sapiens P17612
Y2H Array
32814053
Intra
PLPP1 O14494 PRKACA Homo sapiens P17612
Y2H Pooling
32814053
Intra
PLPP1 O14494 TGIF1 Homo sapiens Q15583
Validated Y2H
32814053
Intra
PLPP1 O14494 TGIF1 Homo sapiens Q15583
Y2H Array
32814053
Intra
PLPP1 O14494 TGIF1 Homo sapiens Q15583
Y2H Pooling
32814053
Intra
PLPP1 O14494 APP Homo sapiens P05067
Validated Y2H
32814053
Intra
PLPP1 O14494 APP Homo sapiens P05067
Y2H Array
32814053
Intra
PLPP1 O14494 APP Homo sapiens P05067
Y2H Pooling
32814053
Intra
PLPP1 O14494 CSNK1D Homo sapiens P48730-2
Y2H Array
32814053
Intra
PLPP1 O14494 CSNK1D Homo sapiens P48730-2
Validated Y2H
32814053
Intra
PLPP1 O14494 CSNK1D Homo sapiens P48730-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

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Diseases Alias
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Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10734 PLPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PLPP1 VGNC VGNC:44705
Mus musculus PLPP1 MGD MGI:108412
Bos taurus PLPP1 VGNC VGNC:33044
Macaca mulatta PLPP1 VGNC VGNC:76226
Rattus norvegicus PLPP1 RGD RGD:621832
Felis catus PLPP1 VGNC VGNC:68972
Others PLPP1 NCBI