2. Gene
  3. Ppp1r1b - protein phosphatase 1, regulatory inhibitor subunit 1B Gene

Ppp1r1b - protein phosphatase 1, regulatory inhibitor subunit 1B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Darpp32; DARPP-32

Gene ID: 19049 | Gene type: protein coding

About Ppp1r1b

Summary

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or Phosphatase Inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders in humans. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Ppp1r1b Products(2)

mRNA Protein Name
NM_001313970.1 NP_001300899.1 protein phosphatase 1 regulatory subunit 1B isoform 2
NM_144828.2 NP_659077.1 protein phosphatase 1 regulatory subunit 1B isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10854268 MGI
acts upstream of or within behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
18496528 MGI
acts upstream of or within cellular response to cocaine IMP
IMP: Inferred from mutant phenotype
18496528 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
18496528 MGI
acts upstream of or within negative regulation of female receptivity IDA
IDA: Inferred from direct assay
10669419 MGI
acts upstream of or within negative regulation of female receptivity IMP
IMP: Inferred from mutant phenotype
10669419 MGI
acts upstream of or within response to amphetamine IGI
IGI: Inferred from genetic interaction
17010100 MGI
acts upstream of or within response to amphetamine IMP
IMP: Inferred from mutant phenotype
18496528 MGI
acts upstream of or within response to morphine IMP
IMP: Inferred from mutant phenotype
18496528 MGI
acts upstream of or within visual learning IGI
IGI: Inferred from genetic interaction
17010100 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18496528 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
18923023 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18496528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 1B

dopamine- and cAMP-regulated neuronal phosphoprotein

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-RS10993 PPP1R1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp1r1b NCBI NCBI:84152