Ppp1r1b - protein phosphatase 1, regulatory inhibitor subunit 1B Gene

Also Known as Darpp32; DARPP-32

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19049

Summary

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or Phosphatase Inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders in humans. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Ppp1r1b Products (2)

mRNA	Protein	Name
NM_001313970.1	NP_001300899.1	protein phosphatase 1 regulatory subunit 1B isoform 2
NM_144828.2	NP_659077.1	protein phosphatase 1 regulatory subunit 1B isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10854268	MGI
acts upstream of or within behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	18496528	MGI
acts upstream of or within cellular response to cocaine	IMP IMP: Inferred from mutant phenotype	18496528	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	18496528	MGI
acts upstream of or within negative regulation of female receptivity	IDA IDA: Inferred from direct assay	10669419	MGI
acts upstream of or within negative regulation of female receptivity	IMP IMP: Inferred from mutant phenotype	10669419	MGI
acts upstream of or within response to amphetamine	IGI IGI: Inferred from genetic interaction	17010100	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	18496528	MGI
acts upstream of or within response to morphine	IMP IMP: Inferred from mutant phenotype	18496528	MGI
acts upstream of or within visual learning	IGI IGI: Inferred from genetic interaction	17010100	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18496528	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	18923023	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18496528	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein phosphatase 1 regulatory subunit 1B	dopamine- and cAMP-regulated neuronal phosphoprotein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100384	NKL 22	Inhibitor	97.26%	Unkown
HY-RS10993	PPP1R1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1r1b	NCBI	NCBI:84152