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Inpp5k - inositol polyphosphate 5-phosphatase K Gene

Also Known as C62; Pps; SKIP

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19062

Summary

Enables inositol bisphosphate Phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; and Vasopressin Receptor activity. Involved in several processes, including negative regulation of phosphate metabolic process; negative regulation of signal transduction; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within glucose homeostasis; in utero embryonic development; and response to Insulin. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Apr 2022]

Inpp5k Products (1)

mRNA	Protein	Name
NM_008916.2	NP_032942.1	inositol polyphosphate 5-phosphatase K

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables inositol bisphosphate phosphatase activity	IMP IMP: Inferred from mutant phenotype	19250614	MGI
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	21938401	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22751929	MGI
enables vasopressin receptor activity	IDA IDA: Inferred from direct assay	21938401	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	21938401	MGI
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	21938401	MGI
involved in cellular response to hormone stimulus	IDA IDA: Inferred from direct assay	21938401	MGI
involved in dephosphorylation	IDA IDA: Inferred from direct assay	21938401	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	18573875	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	19250614	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	18573875	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21938401	MGI
involved in negative regulation of dephosphorylation	IMP IMP: Inferred from mutant phenotype	19250614	MGI
involved in negative regulation of glycogen (starch) synthase activity	IMP IMP: Inferred from mutant phenotype	19250614	MGI
involved in negative regulation of glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	19250614	MGI
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19250614	MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	18573875	MGI
involved in negative regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	19250614	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19250614	MGI
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	21938401	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21938401	MGI
involved in positive regulation of renal water transport	IDA IDA: Inferred from direct assay	21938401	MGI
involved in positive regulation of urine volume	IDA IDA: Inferred from direct assay	21938401	MGI
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	21938401	MGI
involved in regulation of glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	19250614	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	18573875	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21938401	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22247557	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
inositol polyphosphate 5-phosphatase K	PI-5-phosphatase related phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase phosphatidylinositol-4,5-bisphosphate 5-phosphatase putative PI-5-phosphatase skeletal muscle and kidney enriched inositol polyphosphate phosphatase skeletal muscle and k

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06833	INPP5K Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Inpp5k	NCBI	NCBI:51763