2. Gene
  3. Prm2 - protamine 2 Gene

Prm2 - protamine 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Prm-2

Gene ID: 19119 | Gene type: protein coding

About Prm2

Summary

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is synthesized as a precursor and then cleaved to give rise to a family of protamine 2 peptides. [provided by RefSeq, Sep 2015]

Prm2 Products(1)

mRNA Protein Name
NM_008933.2 NP_032959.1 protamine-2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within nucleus organization IMP
IMP: Inferred from mutant phenotype
11326282 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
11326282 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
12620939 MGI
Cellular Component GO Annotation Evidence Reference Source
NOT located in cytoplasm IDA
IDA: Inferred from direct assay
8185929 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
14680821 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10369260 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protamine-2

sperm histone P2

sperm protamine P2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11165 PRM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prm2 NCBI NCBI:5620