PRM2 - protamine 2 Gene

Also Known as CT94.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5620

About PRM2

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,275,639-11,276,480 (from NCBI)

This gene has 2 transcripts (splice variants) and 44 orthologues. Restricted expression toward testis (RPKM 2357.8).

Summary

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015]

PRM2 Products (5)

mRNA Protein Name
NM_001286356.2 NP_001273285.1 protamine-2 isoform 2
NM_001286357.2 NP_001273286.1 protamine-2 isoform 3
NM_001286358.2 NP_001273287.1 protamine-2 isoform 4
NM_001286359.2 NP_001273288.1 protamine-2 isoform 5
NM_002762.4 NP_002753.2 protamine-2 isoform 1

PRM2 Protein Structure

Protamine_P2

Protamine_P2: Sperm histone P2 (1 - 95)

  • 0
  • 102 a.a.
Protein Preferred Names Protein Names

protamine-2

  • cancer/testis antigen family 94, member 2

PRM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRM2 P04554 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
PRM2 P04554 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
PRM2 P04554 KRTAP10-7 Homo sapiens P60409
Validated Y2H
32296183
Intra
PRM2 P04554 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra
PRM2 P04554 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra
PRM2 P04554 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra
PRM2 P04554 SDCBP2 Homo sapiens Q9H190
Validated Y2H
32296183
Intra
PRM2 P04554 SDCBP2 Homo sapiens Q9H190
Y2H Array
32296183
Intra
PRM2 P04554 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Infertility
Varicocele

  • Scrotal Varices

  • Varicoceles

  • Varicocele Of Scrotum

  • Scrotal Varicocele
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Spermatogenic Failure, X-Linked, 1

  • Sertoli Cell-Only Syndrome

  • Germinal Cell Aplasia

  • Del Castillo Syndrome

  • SPGFX1

  • X-Linked Spermatogenic Failure 1

  • Congenital Absence Of Germinal Epithelium Of Testes
Oligoasthenoteratozoospermia

  • Oat

  • Oligoasthenoteratospermia
Pelvic Varices

  • Varix Of Pelvis

  • Pelvic Varicose Vein
Spermatogenic Failure 9

  • Male Infertility Due To Globozoospermia

  • SPGF9

  • Male Infertility Due To Round-Headed Spermatozoa

  • Globozoospermia, Complete

  • Globozoospermia, Total

  • Globozoospermia

  • Globozoospermia Syndrome

  • Round-Headed Sperm Syndrome

  • Globozoospermia Complete

  • Globozoospermia Total
Vas Deferens, Congenital Bilateral Aplasia Of

  • Congenital Bilateral Absence Of Vas Deferens

  • CBAVD

  • Cavd

  • Congenital Bilateral Aplasia Of Vas Deferens

  • Congenital Bilateral Absence Of The Vas Deferens

  • Congenital Bilateral Agenesis Of Vas Deferens

  • Absence Of Vas Deferens

  • Absent Vasa

  • Congenital Absence Of Vas Deferens

  • Congenital Aplasia Of Vas Deferens

  • Absent Vas Deferens

  • Vas Deferens, Congenital Bilateral Absence
Oligospermia
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11165 PRM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRM2 MGD MGI:97766
Bos taurus PRM2 VGNC VGNC:58610
Rattus norvegicus PRM2 RGD RGD:3409