Grin3a - glutamate ionotropic receptor NMDA type subunit 3A Gene

Rattus norvegicus

Also known as NR3; chi-1; GluN3A

Gene ID: 191573 | Gene type: protein coding

About Grin3a

Summary

Enables several functions, including glycine binding activity; ionotropic glutamate receptor activity; and protein Phosphatase 2A binding activity. Contributes to NMDA glutamate receptor activity. Involved in several processes, including calcium ion transport; ionotropic glutamate receptor signaling pathway; and negative regulation of dendritic spine development. Located in postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Orthologous to human GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A). [provided by Alliance of Genome Resources, Apr 2022]

Grin3a Products(2)

mRNA	Protein	Name
NM_001198583.2	NP_001185512.1	glutamate receptor ionotropic, NMDA 3A isoform 2 precursor
NM_138546.2	NP_612555.1	glutamate receptor ionotropic, NMDA 3A isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to NMDA glutamate receptor activity	IDA IDA: Inferred from direct assay	17182766	RGD
enables NMDA glutamate receptor activity	IDA IDA: Inferred from direct assay	16477151	RGD
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	16477151	RGD
enables glycine binding	IDA IDA: Inferred from direct assay	17182766	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17658481	RGD
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	15194871	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transport	IDA IDA: Inferred from direct assay	17182766	RGD
involved in ionotropic glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	16477151	RGD
involved in negative regulation of dendritic spine development	IDA IDA: Inferred from direct assay	24297929	RGD
involved in neuron development	IEP IEP: Inferred from expression pattern	16477151	RGD
involved in rhythmic process	IDA IDA: Inferred from direct assay	16477151	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of NMDA selective glutamate receptor complex	IDA IDA: Inferred from direct assay	16477151	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	16477151	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16617342	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	16617342	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	15194871	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, NMDA 3A

N-methyl-D-aspartate receptor subtype 3A	NMDAR-L
NMDAR-L1	NMDAR3A
NR3 chi-1	NR3A
glutamate [NMDA] receptor subunit 3A	glutamate receptor chi-1
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05806	GRIN3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grin3a	NCBI	NCBI:116443

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