Sftpb - surfactant protein B Gene

Rattus norvegicus

Also known as Sp-b

Gene ID: 192155 | Gene type: protein coding

About Sftpb

Summary

Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in alveolar lamellar body; extracellular space; and multivesicular body. Biomarker of asthma; Bacterial pneumonia; lung disease; newborn respiratory distress syndrome; and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectious disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B). [provided by Alliance of Genome Resources, Apr 2022]

Sftpb Products(1)

mRNA	Protein	Name
NM_138842.2	NP_620197.2	pulmonary surfactant-associated protein B precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	12600831	RGD
involved in cellular response to nitric oxide	IEP IEP: Inferred from expression pattern	15640287	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	12872443	RGD
involved in response to Thyroglobulin triiodothyronine	IEP IEP: Inferred from expression pattern	1850607	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	1850607	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	1850607	RGD
involved in response to epidermal growth factor	IEP IEP: Inferred from expression pattern	19781387	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	10830305	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	10027080	RGD
involved in response to growth factor	IEP IEP: Inferred from expression pattern	17267143	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	11472975	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	14756961	RGD
involved in response to interleukin-6	IEP IEP: Inferred from expression pattern	11000512	RGD
involved in response to leptin	IEP IEP: Inferred from expression pattern	11839533	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11000512	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	10385596	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in alveolar lamellar body	IDA IDA: Inferred from direct assay	2475034	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	11704537	RGD
located in multivesicular body	IDA IDA: Inferred from direct assay	16187065	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pulmonary surfactant-associated protein B

pulmonary surfactant-associated proteolipid SPL(Phe)	surfactant associated protein B
surfactant, pulmonary-associated protein B

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12782	SFTPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22802	Sftpb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sftpb	NCBI	NCBI:6439

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