1. Gene
  2. SFTPB - surfactant protein B Gene

SFTPB - surfactant protein B Gene

Homo sapiens

Also known as SP-B; PSP-B; SFTB3; SFTP3; SMDP1

Gene ID: 6439 | Gene type: protein coding

About SFTPB

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,657,307-85,668,741 (from NCBI)

This gene has 7 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 3 phenotypes. Restricted expression toward lung (RPKM 1420.4).

Summary

This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]

SFTPB Products(3)

mRNA Protein Name
NM_000542.5 NP_000533.4 pulmonary surfactant-associated protein B isoform 1 precursor
NM_001367281.1 NP_001354210.1 pulmonary surfactant-associated protein B isoform 2 precursor
NM_198843.3 NP_942140.3 pulmonary surfactant-associated protein B isoform 1 precursor

SFTPB Protein Structure

SapA

SapA: Saposin A-type domain (43 - 73)

SapB_1

SapB_1: Saposin-like type B, region 1 (78 - 116)

SapB_2

SapB_2: Saposin-like type B, region 2 (122 - 155)

SapB_2

SapB_2: Saposin-like type B, region 2 (345 - 378)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

pulmonary surfactant-associated protein B

18 kDa pulmonary-surfactant protein

Related Diseases

Diseases Alias
Surfactant Metabolism Dysfunction, Pulmonary, 1

Neonatal Acute Respiratory Distress Due To Sp-B Deficiency

SMDP1

Interstitial Lung Disease Due To Surfactant Protein B Deficiency

Pulmonary Alveolar Proteinosis, Congenital, 1

Interstitial Lung Disease, Nonspecific, Due To Surfactant Protein B Deficiency

Neonatal Acute Respiratory Distress Due To Surfactant Protein B Deficiency

Pulmonary Surfactant Metabolism Dysfunction 1

Congenital Pulmonary Alveolar Proteinosis 1

Interstitial Lung Disease Non-Specific Due To Surfactant Protein B Deficiency

Pap

Surfactant Metabolism Dysfunction, Pulmonary, Type 1

Respiratory Distress Syndrome In Premature Infants

Hyaline Membrane Disease

Infant Respiratory Distress Syndrome

Rds Of Prematurity

Hyaline Membrane Disease, Formerly

Infant Acute Respiratory Distress Syndrome

Infant Ards

Neonatal Respiratory Distress Syndrome

Respiratory Distress Syndrome, Infant

RDS

Rds In Prematurity

Respiratory Distress Syndrome, Newborn

Rds - Infants

Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung

Pulmonary Alveolar Proteinosis
Bronchopulmonary Dysplasia

Bpd

Respiratory Failure

Acute Respiratory Failure

Chronic Respiratory Failure

Respiratory Insufficiency

Acute-On-Chronic Respiratory Failure

Respiratory Disease

Acute And Chronic Respiratory Failure

Respiratory Insufficiency/Failure

Chronic Respiratory Disease

Pulmonary Valve Insufficiency

Chronic Disease Of Respiratory System

Respiration Disorders

Respiratory Tract Diseases

Lung Failure Nos

Pulmonary Failure

Arf - [Acute Respiratory Failure]

Acute Respiratory Insufficiency

Acute Pulmonary Insufficiency

Acute Respiration Failure

Chronic Respiration Failure

Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome

Ards

Non-Cardiogenic Pulmonary Edema

Acute Lung Injury

Respiratory Distress Syndrome, Adult

Shock Lung

Acute Respiratory Distress

Respiratory Distress Syndrome

Adult Rds

Ali

Increased-Permeability Pulmonary Edema

Stiff Lung

Respiratory Distress Syndrome Adult

Pulmonary Sclerosing Hemangioma

Pneumocytoma

Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases

Sclerosing Hemangioma

Sclerosing Haemangioma

Cutaneous Fibrous Histiocytoma

Pulmonary Interstitial Emphysema
Newborn Respiratory Distress Syndrome

Hyaline Membrane Disease

Respiratory Distress Syndrome Of Newborn

Neonatal Respiratory Distress

Hmd - Hyaline Membrane Disease

Neonatal Respiratory Distress Syndrome

Pulmonary Hyaline Membrane Disease

Pulmonary Hypoperfusion Syndrome Of Newborn

Respiratory Distress Syndrome, Newborn

Respiratory Distress Syndrome

Cardiorespiratory Distress Syndrome Of Newborn

Distress Respiratory Syndrome Newborn

Idiopathic Respiratory Distress Syndrome

Idiopathic Respiratory Distress Syndrome Of Newborn

Newborn Idiopathic Respiratory Distress Syndrome

Respiratory Distress Syndrome In Newborn

Rds - [Respiratory Distress Syndrome] Of Newborn

Newborn Cardiorespiratory Distress Syndrome

Meconium Aspiration Syndrome

Neonatal Aspiration Of Meconium

Meconium Aspiration

Mas

Meconium Aspiration Syndrome Of Newborn

Meconium Inhalation

Mas - [Meconium Aspiration Syndrome]

Meconium Aspiration Nos

Meconium Aspiration Syndrome Nos

Meconium Pneumonitis

Meconium Stained Liqueur Aspiration

Neonatal Respiratory Failure

Respiratory Failure Of Newborn

Inadequate Pulmonary Ventilation Of Newborn

Newborn Lung Insufficiency

Newborn Pulmonary Function Inadequate

Newborn Pulmonary Insufficiency

Newborn Respiration Failure

Newborn Respiratory Insufficiency

Respiratory Insufficiency Syndrome Of Newborn

Pneumonia

Acute Pneumonia

Pneumonias

Infectious Pneumonia

Pn - [Pneumonia]

Lobar Pneumonia Nos

Multifocal Pneumonia

Orthostatic Pneumonia

Pneumonia Nos

Chronic Pneumonia Nos

Atypical Pneumonia

Passive Pneumonia

Purulent Pneumonia

Interstitial Lobar Pneumonia

Pneumonia, Unspecified

Pneumonia Due To Chlamydia

Pneumonia Due To Chlamydia Pneumoniae

Pneumonia Due To E. Coli

Escherichia Coli Lobar Pneumonia

Pneumonia Due To H. Influenzae

Pneumonia Due To Hemophilus Influenzae

Bronchopneumonia Due To H. Influenzae

Haemophilus Influenzae Lobar Pneumonia

Bronchopneumonia Due To Hemophilus Influenzae

Pseudomonal Pneumonia

Pseudomonas Pneumonia

Pseudomonas Lobar Pneumonia

Staphylococcal Pneumonia

Staphylococcus Pneumonia

Acute Staphylococcal Pneumonia

Staphylococcal Double Pneumonia

Staphylococcal Lobar Pneumonia

Staphylococcal Purulent Pneumonia

Staphylococcal Bronchopneumonia

Pneumococcal Pneumonia

Pneumococcus Pneumonia

Bronchopneumonia Due To S. Pneumoniae

Pneumococcal Lobar Pneumonia

Streptococcal Pneumoniae Pneumonia

Streptococcus Pneumoniae Lobar Pneumonia

Pyemic Pneumococcal Embolism With Pneumonia

Bronchopneumonia Due To Streptococcus Pneumoniae

Pneumonia Due To Streptococcus, Group B

Group B Streptococcal Pneumonia

Adenovirus Pneumonia

Adenoviral Pneumonia

Adenovirus Viral Pneumonia

Pneumonia Respiratory Syncytial Viral

Parainfluenza Viral Pneumonia

Parainfluenzal Pneumonia

Parainfluenza Virus Pneumonia

Human Metapneumovirus Pneumonia

Human Metapneumovirus Infection Resulting In Pneumonia

Pneumocystis Pneumonia

Plasma Cells Pneumonia

Pulmonary Immaturity

Primary Atelectasis Of Newborn

Primary Atelectasis, In Perinatal Period

Primary Failure To Expand Terminal Respiratory Units

Immature Lungs

Primary Atelectasis

Pulmonary Immaturity Nos

Lung Lobe Hypoplasia, Associated With Short Gestation

Lung Nonexpansion

Premature Lungs

Pulmonary Hypoplasia Associated With Short Gestation

Failure Of Expansion Of Terminal Respiratory Units

Primary Atelectasis Of Fetus Or Newborn

Primary Atelectasis In Perinatal Period

Lipid Pneumonia

Exogenous Lipoid Pneumonia

Lipoid Pneumonitis

Pneumonia, Lipid

Pneumonia Lipid

Lipoid Pneumonia

Hemangioma

Hemangiomas

Large Cell Carcinoma

Carcinoma, Large Cell

Carcinoma Large Cell

Toxic Pneumonitis

Acute Chemical Fume Pulmonary Edema

Acute Chemical Pulmonary Edema

Acute Pulmonary Edema Due To Fumes And/Or Vapors

Interstitial Pneumonitis, Desquamative, Familial

Desquamative Interstitial Pneumonia

DIP

Pneumonitis, Desquamative Interstitial, Familial

Pneumonia, Desquamative Interstitial, Familial

Interstitial Lung Disease, Desquamative

Ild, Desquamative

Familial Desquamative Interstitial Pneumonitis

Rbild

Respiratory Bronchiolitis-Associated Interstitial Lung Disease

Respiratory Bronchiolitis Associated Interstitial Lung Disease

Pulmonary Hemosiderosis

Idiopathic Pulmonary Hemosiderosis

Alveolar Hypoventilation Syndrome

Brown Induration

Brown Lung

Siderosis

Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin

Byssinosis

Diaphragm Disease

Abnormality Of The Diaphragm

Disease Of Diaphragm

Diaphragmatic Disorder

Disorder Of Diaphragm

Pulmonary Alveolar Microlithiasis

PULAM

Pam

Respiratory Syncytial Virus Infectious Disease

Respiratory Syncytial Virus Infections

Respiratory Syncytial Virus Infection

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease

COPD

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Chronic Obstructive Lung Disease

Chronic Obstructive Airway Disease

Pulmonary Disease, Chronic Obstructive, Susceptibility To

Cold

Severe Early-Onset Chronic Obstructive Pulmonary Disease

Pulmonary Disease Chronic Obstructive

Pulmonary Disease, Obstructive, Chronic, Susceptibility To

Chronic Obstructive Pulmonary Disease Of Horses

Common Cold

Upper Respiratory Infections

Copd - [Chronic Obstructive Pulmonary Disease]

Coad - [Chronic Obstructive Airways Disease]

Cold - [Chronic Obstructive Lung Disease]

Chronic Airway Disease Nos

Chronic Airways Limitation, Unspecified

Chronic Obstructed Airway, Unspecified

Chronic Obstructive Airway Disease, Unspecified

Chronic Obstructive Airway, Unspecified

Obstructive Lung Disease Nos

Chronic Obstructive Lung Disease Nos

Chronic Obstructive Lung Nos

Obstructive Pulmonary Disease Nos

Exacerbation Copd Nos

Acute Exacerbation Copd

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Aspiration Pneumonitis

Chemical Pneumonitis

Mendelson'S Syndrome

Aspiration Pneumonia

Pneumonitis Due To Fumes And/Or Vapors

Toxic Pneumonitis

Mendelson'S Syndrome Resulting From A Procedure

Mendelson Syndrome Resulting From A Procedure

Pulmonary Acid Aspiration Syndrome

Pneumonitis Due To Inhalation Of Gastric Secretions

Mendelson Syndrome Due To Anaesthesia During Labour And Delivery

Inhalation Of Stomach Contents Or Secretions, Nos Due To Anaesthesia During Labour And Delivery

Pulmonary Hypertension

Primary Pulmonary Hypertension

Hypertension Pulmonary

Hypertension, Pulmonary

Hypertension, Pulmonary, Primary

Idiopathic Pulmonary Hypertension

Idiopathic Pulmonary Arterial Hypertension

Pulmonary Htn - [Hypertension]

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

Cryptogenic Fibrosing Alveolitis

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect

Idiopathic Interstitial Pneumonia

Hamman-Rich Syndrome

Diffuse Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis

Ipf

Idiopathic Interstitial Pneumonias

Idiopathic Interstitial Pneumonia, Not Otherwise Specified

Pulmonary Fibrosis

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2

Acromegaly Due To Pituitary Adenoma 2

Acromegaly, X-Linked

Growth Hormone Secreting Pituitary Adenoma 2

Pituitary Adenoma, Growth Hormone-Secreting, 2

Pituitary Adenoma 2, Gh-Secreting

Gh-Secreting Pituitary Adenoma 2

X-Linked Acromegaly

Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Mesothelioma, Malignant

Malignant Mesothelioma

Pleural Mesothelioma

MESOM

Mesothelioma, Somatic

Advanced Malignant Mesothelioma

Asbestos-Related Malignant Mesothelioma

Diffuse Malignant Mesothelioma

Malignant Tumor Of Mesothelium

Malignant Mesothelioma, Susceptibility To

Mesothelioma Diffuse Malignant

Mesothelioma

Malignant Pleural Mesothelioma

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus

PDA1

Pda

Ductus Arteriosus, Patent

Patent Ductus Arteriosus, Susceptibility To

Patent Ductus Botalli

Patency Of The Ductus Arteriosus

Patent Ductus Arteriosus Familial

Ductus Arteriosus Patent

Patent Ductus Arteriosus - Persisting Type

Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus SFTPB VGNC VGNC:34528
Felis catus SFTPB VGNC VGNC:65066
Canis familiaris SFTPB VGNC VGNC:58285
Rattus norvegicus SFTPB RGD RGD:621700
Macaca mulatta SFTPB VGNC VGNC:77189
Mus musculus SFTPB MGD MGI:109516