Rasgrf1 - RAS protein-specific guanine nucleotide-releasing factor 1 Gene

Also Known as GNRP; P140 RAS-GRF

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 192213

Summary

Enables protein C-terminus binding activity; receptor tyrosine kinase binding activity; and small GTPase binding activity. Involved in several processes, including activation of GTPase activity; cellular response to Insulin stimulus; and response to amphetamine. Located in several cellular components, including apical dendrite; apicolateral plasma membrane; and basolateral plasma membrane. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rasgrf1 Products (2)

mRNA	Protein	Name
NM_001105753.1	NP_001099223.1	ras-specific guanine nucleotide-releasing factor 1 isoform 2
NM_001170531.1	NP_001164002.1	ras-specific guanine nucleotide-releasing factor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10373510	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	10691301	RGD
enables small GTPase binding	IDA IDA: Inferred from direct assay	15798216	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	1379346	RGD
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	19002579	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	19002579	RGD
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	15798216	RGD
involved in positive regulation of Ras protein signal transduction	IDA IDA: Inferred from direct assay	21382555	RGD
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	15798216	RGD
involved in postsynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	14622581	RGD
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	14622581	RGD
involved in regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	21382555	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	19686726	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	12538592	RGD
located in apicolateral plasma membrane	IDA IDA: Inferred from direct assay	9232829	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	9232829	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	14622581	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14622581	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12538592	RGD
is active in postsynapse	EXP EXP: Inferred from Experiment	14622581	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	14622581	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ras-specific guanine nucleotide-releasing factor 1	guanine nucleotide-releasing protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11691	RASGRF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rasgrf1	NCBI	NCBI:5923